Cell Biology Antibodies 6
Anti-NLGN1 Antibody (CAB16105)
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- SKU:
- CAB16105
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NLGN1 Antibody |
| Antibody SKU: | CAB16105 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NLGN1 (NP_055747.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NLGN1 (NP_055747.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YGNV IVIT VNYR LGVL GFLS TGDQ AAKG NYGL LDLI QALR WTSE NIGF FGGD PLRI TVFG SGAG GSCV NLLT LSHY SEGN RWSN STKG LFQR AIAQ SGTA L |
| Gene ID: | 22871 |
| Uniprot: | Q8N2Q7 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, postsynaptic cell membrane, postsynaptic density, synapse |
| Calculated MW: | 92kDa/93kDa |
| Observed MW: | 105kDa |
| Synonyms: | NLGN1, NL1 |
| Background: | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. |
| UniProt Protein Function: | NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q26.31 Cellular Component: cell surface; dendrite; dendritic spine; extracellular space; filopodium tip; Golgi apparatus; integral to plasma membrane; plasma membrane; postsynaptic density; synapse Molecular Function:cell adhesion molecule binding; neurexin binding; PDZ domain binding; protein dimerization activity; receptor activity Biological Process: calcium-dependent cell-cell adhesion; cytoskeletal matrix organization at active zone; establishment of protein localization; heterophilic cell adhesion; nervous system development; neurite development; neuron adhesion; positive regulation of filopodium formation; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein homooligomerization; protein targeting; regulation of neuron differentiation; synaptic vesicle targeting; synaptogenesis |
| NCBI Summary: | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N2Q7 |
| NCBI GenInfo Identifier: | 7662470 |
| NCBI Gene ID: | 22871 |
| NCBI Accession: | NP_055747.1 |
| UniProt Secondary Accession: | Q8N2Q7,Q9UPT2, |
| UniProt Related Accession: | Q8N2Q7 |
| Molecular Weight: | 92,000 Da |
| NCBI Full Name: | neuroligin-1 |
| NCBI Synonym Full Names: | neuroligin 1 |
| NCBI Official Symbol: | NLGN1 |
| NCBI Official Synonym Symbols: | NL1 |
| NCBI Protein Information: | neuroligin-1 |
| UniProt Protein Name: | Neuroligin-1 |
| Protein Family: | Brorin |
| UniProt Gene Name: | NLGN1 |
 | Western blot analysis of extracts of mouse kidney, using NLGN1 antibody (CAB16105) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 6min. |
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