Signal Transduction Antibodies 2
Anti-NKIRAS1 Antibody (CAB14878)
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- SKU:
- CAB14878
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-NKIRAS1 Antibody |
| Antibody SKU: | CAB14878 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-192 of human NKIRAS1 (NP_065078.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-192 of human NKIRAS1 (NP_065078.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LGNK IDLS EQRQ VDAE VAQQ WAKS EKVR LWEV TVTD RKTL IEPF TLLA SKLS QPQS KSSF PLPG RKNK GNSN SEN |
| Gene ID: | 28512 |
| Uniprot: | Q9NYS0 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 21kDa |
| Observed MW: | 22kDa |
| Synonyms: | NKIRAS1, KBRAS1, kappaB-Ras1 |
| Background: |
| UniProt Protein Function: | NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric Chromosomal Location of Human Ortholog: 3p24.2 |
| UniProt Code: | Q9NYS0 |
| NCBI GenInfo Identifier: | 74753075 |
| NCBI Gene ID: | 28512 |
| NCBI Accession: | Q9NYS0.1 |
| UniProt Secondary Accession: | Q9NYS0,Q96K18, |
| UniProt Related Accession: | Q9NYS0 |
| Molecular Weight: | 21,643 Da |
| NCBI Full Name: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
| NCBI Synonym Full Names: | NFKB inhibitor interacting Ras like 1 |
| NCBI Official Symbol: | NKIRAS1 |
| NCBI Official Synonym Symbols: | KBRAS1; kappaB-Ras1 |
| NCBI Protein Information: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
| UniProt Protein Name: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
| UniProt Synonym Protein Names: | I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1 |
| Protein Family: | NF-kappa-B inhibitor-interacting Ras-like protein |
| UniProt Gene Name: | NKIRAS1 |
| UniProt Entry Name: | KBRS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NKIRAS1 antibody (CAB14878) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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