UniProt Protein Function: | NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. |
UniProt Protein Details: | Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric Chromosomal Location of Human Ortholog: 3p24.2 |
UniProt Code: | Q9NYS0 |
NCBI GenInfo Identifier: | 74753075 |
NCBI Gene ID: | 28512 |
NCBI Accession: | Q9NYS0.1 |
UniProt Secondary Accession: | Q9NYS0,Q96K18, |
UniProt Related Accession: | Q9NYS0 |
Molecular Weight: | 21,643 Da |
NCBI Full Name: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
NCBI Synonym Full Names: | NFKB inhibitor interacting Ras like 1 |
NCBI Official Symbol: | NKIRAS1 |
NCBI Official Synonym Symbols: | KBRAS1; kappaB-Ras1 |
NCBI Protein Information: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
UniProt Protein Name: | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
UniProt Synonym Protein Names: | I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1 |
Protein Family: | NF-kappa-B inhibitor-interacting Ras-like protein |
UniProt Gene Name: | NKIRAS1 |
UniProt Entry Name: | KBRS1_HUMAN |