Signal Transduction Antibodies 2

Anti-NKIRAS1 Antibody (CAB14878)

(No reviews yet) Write a Review
SKU:
CAB14878

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NKIRAS1 Antibody
Antibody SKU:CAB14878
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 118-192 of human NKIRAS1 (NP_065078.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse testis, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 118-192 of human NKIRAS1 (NP_065078.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LGNK IDLS EQRQ VDAE VAQQ WAKS EKVR LWEV TVTD RKTL IEPF TLLA SKLS QPQS KSSF PLPG RKNK GNSN SEN
Gene ID:28512
Uniprot:Q9NYS0
Cellular Location:Cytoplasm
Calculated MW:21kDa
Observed MW:22kDa
Synonyms:NKIRAS1, KBRAS1, kappaB-Ras1
Background:
UniProt Protein Function:NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
UniProt Protein Details:

Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 3p24.2

UniProt Code:Q9NYS0
NCBI GenInfo Identifier:74753075
NCBI Gene ID:28512
NCBI Accession:Q9NYS0.1
UniProt Secondary Accession:Q9NYS0,Q96K18,
UniProt Related Accession:Q9NYS0
Molecular Weight:21,643 Da
NCBI Full Name:NF-kappa-B inhibitor-interacting Ras-like protein 1
NCBI Synonym Full Names:NFKB inhibitor interacting Ras like 1
NCBI Official Symbol:NKIRAS1  
NCBI Official Synonym Symbols:KBRAS1; kappaB-Ras1  
NCBI Protein Information:NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Protein Name:NF-kappa-B inhibitor-interacting Ras-like protein 1
UniProt Synonym Protein Names:I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1
Protein Family:NF-kappa-B inhibitor-interacting Ras-like protein
UniProt Gene Name:NKIRAS1  
UniProt Entry Name:KBRS1_HUMAN
Anti-NKIRAS1 Antibody (CAB14878)Western blot analysis of extracts of various cell lines, using NKIRAS1 antibody (CAB14878) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
View AllClose

Additional Information

Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
View AllClose

Related Products