Immunology Antibodies 3
Anti-NKG2D ligand 2 Antibody (CAB8264)
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- SKU:
- CAB8264
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | ULBP2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8264 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP2 (NP_079493.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse ovary, Rat ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP2 (NP_079493.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GRAD PHSL CYDI TVIP KFRP GPRW CAVQ GQVD EKTF LHYD CGNK TVTP VSPL GKKL NVTT AWKA QNPV LREV VDIL TEQL RDIQ LENY TPKE PLTL QARM SCEQ KAEG HSSG SWQF SFDG QIFL LFDS EKRM WTTV HPGA RKMK EKWE NDKV VAMS FHYF SMGD CIGW LEDF LMGM DSTL EPSA GAPL AMS |
| Gene ID: | 80328 |
| Uniprot: | Q9BZM5 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Secreted |
| Calculated MW: | 27kDa |
| Observed MW: | 30kDa |
| Synonyms: | ULBP2, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H |
| Background: | This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. |
| UniProt Protein Function: | ULBP2: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6q25 Cellular Component: anchored to plasma membrane; cell surface; extracellular space Molecular Function:antigen binding; natural killer cell lectin-like receptor binding Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity |
| NCBI Summary: | This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q9BZM5 |
| NCBI GenInfo Identifier: | 47605923 |
| NCBI Gene ID: | 80328 |
| NCBI Accession: | Q9BZM5.1 |
| UniProt Secondary Accession: | Q9BZM5,Q5VUN4, |
| UniProt Related Accession: | Q9BZM5 |
| Molecular Weight: | 27,368 Da |
| NCBI Full Name: | NKG2D ligand 2 |
| NCBI Synonym Full Names: | UL16 binding protein 2 |
| NCBI Official Symbol: | ULBP2 |
| NCBI Official Synonym Symbols: | N2DL2; RAET1H; NKG2DL2; ALCAN-alpha |
| NCBI Protein Information: | NKG2D ligand 2 |
| UniProt Protein Name: | NKG2D ligand 2 |
| UniProt Synonym Protein Names: | ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2 |
| Protein Family: | NKG2D ligand |
| UniProt Gene Name: | ULBP2 |
| UniProt Entry Name: | N2DL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ULBP2 antibody (CAB8264) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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