Immunology Antibodies 3

Anti-NKG2D ligand 2 Antibody (CAB8264)

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SKU:
CAB8264
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:ULBP2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8264
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP2 (NP_079493.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse ovary, Rat ovary
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP2 (NP_079493.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GRAD PHSL CYDI TVIP KFRP GPRW CAVQ GQVD EKTF LHYD CGNK TVTP VSPL GKKL NVTT AWKA QNPV LREV VDIL TEQL RDIQ LENY TPKE PLTL QARM SCEQ KAEG HSSG SWQF SFDG QIFL LFDS EKRM WTTV HPGA RKMK EKWE NDKV VAMS FHYF SMGD CIGW LEDF LMGM DSTL EPSA GAPL AMS
Gene ID:80328
Uniprot:Q9BZM5
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor, Secreted
Calculated MW:27kDa
Observed MW:30kDa
Synonyms:ULBP2, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H
Background:This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.
UniProt Protein Function:ULBP2: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; cell surface; extracellular space

Molecular Function:antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity

NCBI Summary:This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
UniProt Code:Q9BZM5
NCBI GenInfo Identifier:47605923
NCBI Gene ID:80328
NCBI Accession:Q9BZM5.1
UniProt Secondary Accession:Q9BZM5,Q5VUN4,
UniProt Related Accession:Q9BZM5
Molecular Weight:27,368 Da
NCBI Full Name:NKG2D ligand 2
NCBI Synonym Full Names:UL16 binding protein 2
NCBI Official Symbol:ULBP2  
NCBI Official Synonym Symbols:N2DL2; RAET1H; NKG2DL2; ALCAN-alpha  
NCBI Protein Information:NKG2D ligand 2
UniProt Protein Name:NKG2D ligand 2
UniProt Synonym Protein Names:ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2
Protein Family:NKG2D ligand
UniProt Gene Name:ULBP2  
UniProt Entry Name:N2DL2_HUMAN
Anti-NKG2D ligand 2 Polyclonal Antibody (CAB8264)Western blot analysis of extracts of various cell lines, using ULBP2 antibody (CAB8264) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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