Cell Biology Antibodies 17
Anti-NKD2 Antibody (CAB18517)
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- SKU:
- CAB18517
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NKD2 Antibody |
| Antibody SKU: | CAB18517 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human NKD2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human NKD2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 85409 |
| Uniprot: | Q969F2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | Naked2, NKD2 |
| Background: |
| UniProt Protein Function: | NKD2: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Interacts with RNF25 and TGFA (via cytoplasmic domain). Expressed in kidney, lung, pancreas and spleen. Belongs to the NKD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5p15.3 Cellular Component: basolateral plasma membrane; cytoplasmic vesicle; lateral plasma membrane Molecular Function:growth factor binding; protein binding; ubiquitin protein ligase binding Biological Process: Golgi vesicle fusion to target membrane; positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q969F2 |
| NCBI GenInfo Identifier: | 74716653 |
| NCBI Gene ID: | 85409 |
| NCBI Accession: | Q969F2.1 |
| UniProt Secondary Accession: | Q969F2,Q96EK8, Q9BSN0, |
| UniProt Related Accession: | Q969F2 |
| Molecular Weight: | 34,314 Da |
| NCBI Full Name: | Protein naked cuticle homolog 2 |
| NCBI Synonym Full Names: | naked cuticle homolog 2 |
| NCBI Official Symbol: | NKD2 |
| NCBI Official Synonym Symbols: | Naked2 |
| NCBI Protein Information: | protein naked cuticle homolog 2 |
| UniProt Protein Name: | Protein naked cuticle homolog 2 |
| Protein Family: | Protein naked cuticle |
| UniProt Gene Name: | NKD2 |
| UniProt Entry Name: | NKD2_HUMAN |
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