Epigenetics & Nuclear Signaling Antibodies 2
Anti-NHP2L1 Antibody (CAB5926)
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- SKU:
- CAB5926
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NHP2L1 Antibody |
| Antibody SKU: | CAB5926 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human NHP2L1 (NP_004999.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2, NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human NHP2L1 (NP_004999.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEA DVNP KAYP LADA HLTK KLLD LVQQ SCNY KQLR KGAN EATK TLNR GISE FIVM AADA EPLE IILH LPLL CEDK NVPY VFVR SKQA LGRA CGVS RPVI ACSV TIKE GSQL KQQI QSIQ QSIE RLLV |
| Gene ID: | 4809 |
| Uniprot: | P55769 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 14kDa |
| Observed MW: | 14kDa |
| Synonyms: | SNU13, 15.5K, FA-1, FA1, NHP2L1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1 |
| Background: | Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | NHP2L1: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Belongs to the ribosomal protein L7Ae family. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding; Nucleolus; Spliceosome Chromosomal Location of Human Ortholog: 22q13 Cellular Component: nucleoplasm; spliceosome; protein complex; nucleolus; nucleus Molecular Function:snoRNA binding; protein binding; RNA binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; ribosome biogenesis and assembly; gene expression |
| NCBI Summary: | Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55769 |
| NCBI GenInfo Identifier: | 2500345 |
| NCBI Gene ID: | 4809 |
| NCBI Accession: | P55769.3 |
| UniProt Related Accession: | P55769 |
| Molecular Weight: | Calculated: 14kDaObserved: 14kDa |
| NCBI Full Name: | NHP2-like protein 1 |
| NCBI Synonym Full Names: | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) |
| NCBI Official Symbol: | NHP2L1 |
| NCBI Official Synonym Symbols: | FA1; FA-1; NHPX; 15.5K; OTK27; SNU13; SSFA1; SPAG12; SNRNP15-5 |
| NCBI Protein Information: | NHP2-like protein 1; sperm specific antigen 1; U4/U6.U5 tri-snRNP 15.5 kDa protein; non-histone chromosome protein 2-like 1; [U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein; small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5); high mobility group-like nuclear protein 2 homolog 1 |
| UniProt Protein Name: | NHP2-like protein 1 |
| UniProt Synonym Protein Names: | High mobility group-like nuclear protein 2 homolog 1; OTK27; SNU13 homolog; hSNU13; U4/U6.U5 tri-snRNP 15.5 kDa proteinNHP2-like protein 1, N-terminally processed |
| UniProt Gene Name: | NHP2L1 |
| UniProt Entry Name: | NH2L1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NHP2L1 antibody (CAB5926) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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