Developmental Biology
Anti-NHLH1 Antibody (CAB15695)
- SKU:
- CAB15695
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-NHLH1 Antibody |
| Antibody SKU: | CAB15695 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human NHLH1 (NP_005589.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human NHLH1 (NP_005589.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMLN SDTM ELDL PPTH SETE SGFS DCGG GAGP DGAG PGGP GGGQ ARGP EPGE PGRK DLQH |
| Gene ID: | 4807 |
| Uniprot: | Q02575 |
| Cellular Location: | Nucleus |
| Calculated MW: | 14kDa |
| Observed MW: | 15kDa |
| Synonyms: | NHLH1, HEN1, NSCL, NSCL1, bHLHa35 |
| Background: | The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040). |
| UniProt Protein Function: | NHLH1: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q22 Cellular Component: nucleus Biological Process: central nervous system development; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002] |
| UniProt Code: | Q02575 |
| NCBI GenInfo Identifier: | 399885 |
| NCBI Gene ID: | 4807 |
| NCBI Accession: | Q02575.1 |
| UniProt Related Accession: | Q02575 |
| Molecular Weight: | 14,618 Da |
| NCBI Full Name: | Helix-loop-helix protein 1 |
| NCBI Synonym Full Names: | nescient helix-loop-helix 1 |
| NCBI Official Symbol: | NHLH1 |
| NCBI Official Synonym Symbols: | HEN1; NSCL; NSCL1; bHLHa35 |
| NCBI Protein Information: | helix-loop-helix protein 1 |
| UniProt Protein Name: | Helix-loop-helix protein 1 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1 |
| Protein Family: | Helix-loop-helix protein |
| UniProt Gene Name: | NHLH1 |
| UniProt Entry Name: | HEN1_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using NHLH1 antibody (CAB15695) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
NHLH1 Monoclonal Antibody
OverviewProduct Name:NHLH1 Monoclonal AntibodyProduct Code:CAB24828Reactivity:HumanApplications:Western blotting, Immunofluoresce
