Epigenetics & Nuclear Signaling Antibodies 3
Anti-NHEJ1 Antibody (CAB4985)
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- SKU:
- CAB4985
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NHEJ1
- Synonyms:
- XLF
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | NHEJ1 Rabbit pAb |
| Product Code: | CAB4985 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NHEJ1, XLF |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human NHEJ1 (NP_079058.1). |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Hela, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human NHEJ1 (NP_079058.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEL EQGL LMQP WAWL QLAE NSLL AKVF ITKQ GYAL LVSD LQQV WHEQ VDTS VVSQ RAKE LNKR LTAP PAAF LCHL DNLL RPLL KDAA HPSE ATFS CDCV ADAL ILRV RSEL SGLP FYWN FHCM LASP SLVS QHLI RPLM GMSL ALQC QVRE LATL LHMK DLEI QDYQ ESGA TLIR DRLK TEPF EENS FLEQ FMIE KLPE ACSI GDGK PFVM NLQD LYMA VTTQ EVQV GQKH QGAG DPHT SNSA SLQG IDSQ CVNQ PEQL VSSA PTLS APEK ESTG TSGP LQRP QLSK VKRK KPRG LFS |
| Gene ID: | 79840 |
| Uniprot: | Q9H9Q4 |
| Cellular Location: | Nucleus |
| Calculated MW: | 33kDa/35kDa |
| Observed MW: | 38kDa |
| UniProt Protein Function: | NHEJ1: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner. Ubiquitously expressed. Belongs to the XLF family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleus Molecular Function:protein binding; DNA binding Biological Process: central nervous system development; B cell differentiation; response to ionizing radiation; positive regulation of ligase activity; double-strand break repair via nonhomologous end joining; DNA recombination; T cell differentiation Disease: Severe Combined Immunodeficiency With Microcephaly, Growth Retardation, And Sensitivity To Ionizing Radiation |
| NCBI Summary: | Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H9Q4 |
| NCBI GenInfo Identifier: | 74734059 |
| NCBI Gene ID: | 79840 |
| NCBI Accession: | Q9H9Q4.1 |
| UniProt Secondary Accession: | Q9H9Q4,Q4ZFW7, Q6IA64, Q96JS9, B8ZZA4, |
| UniProt Related Accession: | Q9H9Q4 |
| Molecular Weight: | 299 |
| NCBI Full Name: | Non-homologous end-joining factor 1 |
| NCBI Synonym Full Names: | nonhomologous end-joining factor 1 |
| NCBI Official Symbol: | NHEJ1 |
| NCBI Official Synonym Symbols: | XLF |
| NCBI Protein Information: | non-homologous end-joining factor 1; XRCC4-like factor; protein cernunnos |
| UniProt Protein Name: | Non-homologous end-joining factor 1 |
| UniProt Synonym Protein Names: | Protein cernunnos; XRCC4-like factor |
| Protein Family: | Non-homologous end-joining factor |
| UniProt Gene Name: | NHEJ1 |
| UniProt Entry Name: | NHEJ1_HUMAN |
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