Epigenetics & Nuclear Signaling Antibodies 2

Anti-NFE2L3 Antibody (CAB15761)

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SKU:
CAB15761
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NFE2L3 Antibody
Antibody SKU:CAB15761
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-550 of human NFE2L3 (NP_004280.5).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, U-251MG, Mouse testis, Rat brain, Rat thymus, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-550 of human NFE2L3 (NP_004280.5).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HYHV NFSQ AISQ DVNL HEAI LLCP NNTF RRDP TART SQSQ EPFL QLNS HTTN PEQT LPGT NLTG FLSP VDNH MRNL TSQD LLYD LDIN IFDE INLM SLAT EDNF DPID VSQL FDEP DSDS GLSL DSSH NNTS VIKS NSSH SVCD EGAI GYCT DHES SSHH DLEG AVGG YYPE PSKL CHLD QSDS DFHG DLTF QHVF HNHT YHLQ PTAP ESTS EPFP WPGK SQKI RSRY LEDT DRNL SRDE QRAK ALHI PFS
Gene ID:9603
Uniprot:Q9Y4A8
Cellular Location:Nucleus
Calculated MW:76kDa
Observed MW:84kDa
Synonyms:NFE2L3, NRF3
Background:This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.
UniProt Protein Function:NFE2L3: Activates erythroid-specific, globin gene expression. Belongs to the bZIP family. CNC subfamily.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleus

Molecular Function:transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter

UniProt Code:Q9Y4A8
NCBI GenInfo Identifier:225735557
NCBI Gene ID:
NCBI Accession:NP_004280.5
Molecular Weight:~ 76kDa
NCBI Full Name:nuclear factor erythroid 2-related factor 3
UniProt Protein Name:Nuclear factor erythroid 2-related factor 3
UniProt Synonym Protein Names:Nuclear factor, erythroid derived 2, like 3
UniProt Gene Name:NFE2L3  
UniProt Entry Name:NF2L3_HUMAN
Anti-NFE2L3 Antibody (CAB15761)Western blot analysis of extracts of various cell lines, using NFE2L3 antibody (CAB15761) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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