Metabolism Antibodies 1
Anti-NFE2L1 Antibody (CAB14753)
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- SKU:
- CAB14753
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-NFE2L1 Antibody |
| Antibody SKU: | CAB14753 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 515-772 of human NFE2L1 (NP_003195.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, PC-12, Mouse fat, Mouse lung, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 515-772 of human NFE2L1 (NP_003195.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SSSF SEEG AVGY SSDS ETLD LEEA EGAV GYQP EYSK FCRM SYQD PAQL SCLP YLEH VGHN HTYN MAPS ALDS ADLP PPSA LKKG SKEK QADF LDKQ MSRD EHRA RAMK IPFT NDKI INLP VEEF NELL SKYQ LSEA QLSL IRDI RRRG KNKM AAQN CRKR KLDT ILNL ERDV EDLQ RDKA RLLR EKVE FLRS LRQM KQKV QSLY QEVF GRLR DENG RPYS PSQY ALQY AGDG SVLL IPRT MADQ QARR QERK PKDR RK |
| Gene ID: | 4779 |
| Uniprot: | Q14494 |
| Cellular Location: | Endoplasmic reticulum membrane, Nucleus, Single-pass type II membrane protein |
| Calculated MW: | 81kDa/84kDa |
| Observed MW: | 64kDa |
| Synonyms: | NFE2L1, LCR-F1, NRF1, TCF11 |
| Background: | This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. |
| UniProt Protein Function: | NFE2L1: Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; transcription cofactor activity; transcription factor activity Biological Process: anatomical structure morphogenesis; heme biosynthetic process; inflammatory response; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14494 |
| NCBI GenInfo Identifier: | 3183180 |
| NCBI Gene ID: | 4779 |
| NCBI Accession: | Q14494.1 |
| UniProt Secondary Accession: | Q14494,Q12877, Q96FN6, D3DTU3, D3DTU5, |
| UniProt Related Accession: | Q14494 |
| Molecular Weight: | 81,499 Da |
| NCBI Full Name: | Nuclear factor erythroid 2-related factor 1 |
| NCBI Synonym Full Names: | nuclear factor, erythroid 2 like 1 |
| NCBI Official Symbol: | NFE2L1 |
| NCBI Official Synonym Symbols: | NRF1; TCF11; LCR-F1 |
| NCBI Protein Information: | nuclear factor erythroid 2-related factor 1 |
| UniProt Protein Name: | Nuclear factor erythroid 2-related factor 1 |
| UniProt Synonym Protein Names: | Locus control region-factor 1; Nuclear factor, erythroid derived 2, like 1; Transcription factor 11; TCF-11; Transcription factor HBZ17; Transcription factor LCR-F1 |
| Protein Family: | Nuclear factor erythroid 2-related factor |
| UniProt Gene Name: | NFE2L1 |
| UniProt Entry Name: | NF2L1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NFE2L1 antibody (CAB14753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat heart using NFE2L1 antibody (CAB14753) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using NFE2L1 antibody (CAB14753) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NFE2L1 antibody (CAB14753) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using NFE2L1 antibody (CAB14753) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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