Cell Biology Antibodies 6
Anti-NFATC2IP Antibody (CAB16155)
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- SKU:
- CAB16155
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NFATC2IP Antibody |
| Antibody SKU: | CAB16155 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-360 of human NFATC2IP (NP_116204.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-360 of human NFATC2IP (NP_116204.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDHM ATHL GVSP SRIL LLFG ETEL SPTA TPRT LKLG VADI IDCV VLTS SPEA TETS QQLQ LRVQ GKEK HQT |
| Gene ID: | 84901 |
| Uniprot: | Q8NCF5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 13kDa/15kDa/45kDa |
| Observed MW: | 45kDa |
| Synonyms: | NFATC2IP, ESC2, NIP45, RAD60 |
| Background: |
| UniProt Protein Function: | NFATC2IP: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasm; nucleus Biological Process: cytokine production; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q8NCF5 |
| NCBI GenInfo Identifier: | 51873914 |
| NCBI Gene ID: | 84901 |
| NCBI Accession: | AAH80628.1 |
| UniProt Secondary Accession: | Q8NCF5,O09130, Q6AYG7, |
| UniProt Related Accession: | Q8NCF5 |
| Molecular Weight: | 45,817 Da |
| NCBI Full Name: | NFATC2IP protein, partial |
| NCBI Synonym Full Names: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein |
| NCBI Official Symbol: | NFATC2IP |
| NCBI Official Synonym Symbols: | ESC2; NIP45; RAD60 |
| NCBI Protein Information: | NFATC2-interacting protein; 45 kDa NFAT-interacting protein; 45 kDa NF-AT-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein |
| UniProt Protein Name: | NFATC2-interacting protein |
| UniProt Synonym Protein Names: | 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein |
| UniProt Gene Name: | NFATC2IP |
| UniProt Entry Name: | NF2IP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NFATC2IP antibody (CAB16155) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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