Epigenetics & Nuclear Signaling Antibodies 3

Anti-NFAT5 Antibody (CAB16649)

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SKU:
CAB16649
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NFAT5 Antibody
Antibody SKU:CAB16649
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1300 to the C-terminus of human NFAT5 (NP_619728.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SH-SY5Y, A-549
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1300 to the C-terminus of human NFAT5 (NP_619728.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSPA SMSA LQTS INQQ DMQQ SPLY SPQN NMPG IQGA TSSP QPQA TLFH NTAG GTMN QLQN SPGS SQQT SGMF LFGI QNNC SQLL TSGP ATLP DQLM AISQ PGQP QNEG QPPV TTLL SQQM PENS PLAS SINT NQNI EKID LLVS LQNQ GNNL TGSF
Gene ID:10725
Uniprot:O94916
Cellular Location:
Calculated MW:10kDa/157kDa/165kDa/167kDa
Observed MW:174kDa
Synonyms:NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
Background:The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
NCBI Summary:The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O94916
NCBI GenInfo Identifier:9087151
NCBI Gene ID:10725
NCBI Accession:O94916.1
UniProt Secondary Accession:O94916,O95693, Q7LA65, Q969Q8, Q96QH3, Q9UN18, A2RRB4 A6H8V5, E9PHR7,
UniProt Related Accession:O94916
Molecular Weight:167,808 Da
NCBI Full Name:Nuclear factor of activated T-cells 5
NCBI Synonym Full Names:nuclear factor of activated T-cells 5, tonicity-responsive
NCBI Official Symbol:NFAT5  
NCBI Official Synonym Symbols:NFATZ; OREBP; NF-AT5; NFATL1; TONEBP  
NCBI Protein Information:nuclear factor of activated T-cells 5
UniProt Protein Name:Nuclear factor of activated T-cells 5
UniProt Synonym Protein Names:T-cell transcription factor NFAT5; Tonicity-responsive enhancer-binding protein; TonE-binding protein; TonEBP
Protein Family:Nuclear factor of activated T-cells
UniProt Gene Name:NFAT5  
UniProt Entry Name:NFAT5_HUMAN
Anti-NFAT5 Antibody (CAB16649)Western blot analysis of extracts of various cell lines, using NFAT5 antibody (CAB16649) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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