Cell Biology Antibodies 11
Anti-Neuroplastin Antibody (CAB7972)
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- SKU:
- CAB7972
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | NPTN Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7972 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-200 of human NPTN (NP_059429.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-200 of human NPTN (NP_059429.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QNEP RIVT SEEV IIRD SPVL PVTL QCNL TSSS HTLT YSYW TKNG VELS ATRK NASN MEYR INKP RAED SGEY HCVY HFVS APKA NATI EVKA APDI TGHK RSEN KNEG QDAT MYCK SVGY PHPD WIWR KKEN GMPM DIVN TSGR FFII NKEN YTEL NIVN LQIT EDPG EYEC |
| Gene ID: | 27020 |
| Uniprot: | Q9Y639 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 30kDa/31kDa/37kDa/43kDa/44kDa |
| Observed MW: | 45kDa |
| Synonyms: | NPTN, GP55, GP65, SDFR1, SDR1, np55, np65 |
| Background: | This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | neuroplastin: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cell surface; presynaptic membrane Molecular Function:cell adhesion molecule binding; type 1 fibroblast growth factor receptor binding Biological Process: elevation of cytosolic calcium ion concentration; homophilic cell adhesion; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009] |
| UniProt Code: | Q9Y639 |
| NCBI GenInfo Identifier: | 298286871 |
| NCBI Gene ID: | 27020 |
| NCBI Accession: | Q9Y639.2 |
| UniProt Secondary Accession: | Q9Y639,Q17R52, Q59EJ9, Q6NVX7, Q9Y640, B2RAL7, B7Z4D3 B7ZLL2, |
| UniProt Related Accession: | Q9Y639 |
| Molecular Weight: | 43,931 Da |
| NCBI Full Name: | Neuroplastin |
| NCBI Synonym Full Names: | neuroplastin |
| NCBI Official Symbol: | NPTN |
| NCBI Official Synonym Symbols: | GP55; GP65; SDR1; np55; np65; SDFR1 |
| NCBI Protein Information: | neuroplastin |
| UniProt Protein Name: | Neuroplastin |
| UniProt Synonym Protein Names: | Stromal cell-derived receptor 1; SDR-1 |
| Protein Family: | Neuroplastin |
| UniProt Gene Name: | NPTN |
 | Western blot analysis of extracts of various cell lines, using NPTN antibody (CAB7972) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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