Cell Biology Antibodies 12
Anti-Neurogranin Antibody (CAB8444)
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- SKU:
- CAB8444
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Neurogranin Antibody |
| Antibody SKU: | CAB8444 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human NRGN (NP_001119653.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, U-251MG, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-78 of human NRGN (NP_001119653.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDCC TENA CSKP DDDI LDIP LDDP GANA AAAK IQAS FRGH MARK KIKS GERG RKGP GPGG PGGA GVAR GGAG GGPS GD |
| Gene ID: | 4900 |
| Uniprot: | Q92686 |
| Cellular Location: | |
| Calculated MW: | 7kDa |
| Observed MW: | 14kDa |
| Synonyms: | NRGN, RC3, hng |
| Background: | Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. |
| UniProt Protein Function: | neurogranin: Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Belongs to the neurogranin family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 11q24 Biological Process: nervous system development; signal transduction |
| NCBI Summary: | Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92686 |
| NCBI GenInfo Identifier: | 2498625 |
| NCBI Gene ID: | 4900 |
| NCBI Accession: | Q92686.1 |
| UniProt Related Accession: | Q92686 |
| Molecular Weight: | 7,618 Da |
| NCBI Full Name: | Neurogranin |
| NCBI Synonym Full Names: | neurogranin |
| NCBI Official Symbol: | NRGN |
| NCBI Official Synonym Symbols: | RC3; hng |
| NCBI Protein Information: | neurogranin |
| UniProt Protein Name: | Neurogranin |
| UniProt Synonym Protein Names: | RC3 |
| Protein Family: | Neurogranin |
| UniProt Gene Name: | NRGN |
| UniProt Entry Name: | NEUG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NRGN antibody (CAB8444) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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