Developmental Biology

Anti-NEUROG3 Antibody (CAB2772)

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SKU:
CAB2772
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-NEUROG3 Antibody
Antibody SKU:CAB2772
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human NEUROG3 (NP_066279.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, 293T, H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human NEUROG3 (NP_066279.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTPQ PSGA PTVQ VTRE TERS FPRA SEDE VTCP TSAP PSPT RTRG NCAE AEEG GCRG APRK LRAR RGGR SRPK SELA LSKQ RRS
Gene ID:50674
Uniprot:Q9Y4Z2
Cellular Location:Nucleus
Calculated MW:23kDa
Observed MW:23kDa
Synonyms:NEUROG3, Atoh5, Math4B, NGN-3, bHLHa7, ngn3
Background:The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).
UniProt Protein Function:neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
UniProt Protein Details:

Protein type:Cell development/differentiation; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: cytoplasm; nucleus

Molecular Function:protein dimerization activity; chromatin DNA binding; double-stranded DNA binding; transcription coactivator activity

Biological Process: nervous system development; central nervous system development; transcription, DNA-dependent; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; peripheral nervous system development; epithelial cell differentiation; spinal cord development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; hindbrain development

Disease: Diarrhea 4, Malabsorptive, Congenital

NCBI Summary:The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
UniProt Code:Q9Y4Z2
NCBI GenInfo Identifier:229462908
NCBI Gene ID:50674
NCBI Accession:Q9Y4Z2.2
UniProt Secondary Accession:Q9Y4Z2,Q5VVI0, Q6DJX6, Q9BY24,
UniProt Related Accession:Q9Y4Z2
Molecular Weight:214
NCBI Full Name:Neurogenin-3
NCBI Synonym Full Names:neurogenin 3
NCBI Official Symbol:NEUROG3  
NCBI Official Synonym Symbols:ngn3; Atoh5; NGN-3; Math4B; bHLHa7  
NCBI Protein Information:neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7
UniProt Protein Name:Neurogenin-3
UniProt Synonym Protein Names:Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5
UniProt Gene Name:NEUROG3  
UniProt Entry Name:NGN3_HUMAN
Anti-NEUROG3 Antibody (CAB2772)Western blot analysis of extracts of various cell lines, using NEUROG3 antibody (CAB2772) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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