Anti-Neurofilament L Antibody (CAB20269)

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SKU:
CAB20269
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NEFL
Synonyms:
CMT1F
Synonyms:
CMT2E
Synonyms:
NF-L
Synonyms:
NF68
Synonyms:
NFL
Synonyms:
PPP1R110
Research Area:
Cell Biology

Description

Product Name:Neurofilament L Rabbit mAb
Product Code:CAB20269
Size:20uL, 50uL, 100uL
Synonyms:NEFL, CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110
Applications:WB, IHC, IF, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human Neurofilament L.
Applications:WB, IHC, IF, IP
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse brain, Rat brain
Immunogen:Recombinant protein of human Neurofilament L.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4747
Uniprot:P07196
Observed MW:70KDa
UniProt Protein Function:NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F).
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: TSC1-TSC2 complex; growth cone; axon; cytoplasm; neurofilament; cytosol

Molecular Function:protein C-terminus binding; protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; phospholipase binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; response to peptide hormone stimulus; neurofilament bundle assembly; response to toxin; intermediate filament organization; microtubule cytoskeleton organization and biogenesis; retrograde axon cargo transport; axon regeneration in the peripheral nervous system; synaptic transmission; axon transport of mitochondrion; regulation of axon diameter; positive regulation of axonogenesis; negative regulation of neuron apoptosis; anterograde axon cargo transport; neuromuscular process controlling balance; locomotion; neurite morphogenesis; response to corticosterone stimulus

Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f

NCBI Summary:Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
UniProt Code:P07196
NCBI GenInfo Identifier:62511894
NCBI Gene ID:4747
NCBI Accession:P07196.3
UniProt Related Accession:P07196
Molecular Weight:
NCBI Full Name:Neurofilament light polypeptide
NCBI Synonym Full Names:neurofilament light
NCBI Official Symbol:NEFL  
NCBI Official Synonym Symbols:NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110  
NCBI Protein Information:neurofilament light polypeptide
UniProt Protein Name:Neurofilament light polypeptide
UniProt Synonym Protein Names:68 kDa neurofilament protein; Neurofilament triplet L protein
Protein Family:Neurofilament heavy polypeptide
UniProt Gene Name:NEFL  
UniProt Entry Name:NFL_HUMAN
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