Signal Transduction Antibodies 1

Anti-NEURL2 Antibody (CAB14450)

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SKU:
CAB14450
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-NEURL2 Antibody
Antibody SKU:CAB14450
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 181-285 of human NEURL2 (NP_542787.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse skeletal muscle, Mouse heart, Mouse brain, Rat skeletal muscle, Rat heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 181-285 of human NEURL2 (NP_542787.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPPT ARRS RLGV LFCP RPDG TADM HIII NGED MGPS ARGL PAAQ PLYA VVDV FAST KSVR LVQL EYGL PSLQ TLCR LVIQ RSMV HRLA IDGL HLPK ELKD FCKY E
Gene ID:140825
Uniprot:Q9BR09
Cellular Location:Cytoplasm
Calculated MW:31kDa
Observed MW:32kDa
Synonyms:NEURL2, C20orf163, OZZ, OZZ-E3
Background:This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:NEURL2: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: muscle tendon junction; VCB complex

Biological Process: protein ubiquitination; sarcomere organization

NCBI Summary:This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q9BR09
NCBI GenInfo Identifier:33301415
NCBI Gene ID:
NCBI Accession:Q9BR09.1
UniProt Secondary Accession:Q9BR09,Q3KR34,
Molecular Weight:31,690 Da
NCBI Full Name:Neuralized-like protein 2
UniProt Protein Name:Neuralized-like protein 2
Protein Family:Neuralized-like protein
UniProt Gene Name:NEURL2  
UniProt Entry Name:NEUL2_HUMAN
Anti-NEURL2 Antibody (CAB14450)Western blot analysis of extracts of various cell lines, using NEURL2 antibody (CAB14450) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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