Metabolism Antibodies 2
Anti-NEU4 Antibody (CAB5141)
- SKU:
- CAB5141
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-NEU4 Antibody |
| Antibody SKU: | CAB5141 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-496 of human NEU4 (NP_542779.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, 293T, Mouse pancreas, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-496 of human NEU4 (NP_542779.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ECFG KICR TSPH SFAF YSDD HGRT WRCG GLVP NLRS GECQ LAAV DGGQ AGSF LYCN ARSP LGSR VQAL STDE GTSF LPAE RVAS LPET AWGC QGSI VGFP APAP NRPR DDSW SVGP GSPL QPPL LGPG VHEP PEEA AVDP RGGQ VPGG PFSR LQPR GDGP RQPG PRPG VSGD VGSW TLAL PMPF AAPP QSPT WLLY SHPV GRRA RLHM GIRL SQSP LDPR SWTE PWVI YEGP SGYS DLAS IGPA PEGG LVFA CLYE SGAR TSYD EISF CTFS LREV LENV PASP KPPN LGDK PRGC CWPS |
| Gene ID: | 129807 |
| Uniprot: | Q8WWR8 |
| Cellular Location: | Lysosome lumen, Membrane, Peripheral membrane protein |
| Calculated MW: | 51kDa/52kDa/53kDa |
| Observed MW: | 51kDa |
| Synonyms: | NEU4 |
| Background: | The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | NEU4: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. Belongs to the glycosyl hydrolase 33 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - sphingolipid; EC 3.2.1.18; Hydrolase; Glycan Metabolism - other glycan degradation Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: lysosomal lumen; organelle inner membrane; mitochondrion; lysosome Molecular Function:protein binding; exo-alpha-sialidase activity Biological Process: oligosaccharide catabolic process; cellular protein metabolic process; sphingolipid metabolic process; dolichol-linked oligosaccharide biosynthetic process; ganglioside catabolic process; glycosphingolipid metabolic process; protein amino acid N-linked glycosylation via asparagine; glycoprotein catabolic process; post-translational protein modification |
| NCBI Summary: | The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q8WWR8 |
| NCBI GenInfo Identifier: | 262527265 |
| NCBI Gene ID: | 129807 |
| NCBI Accession: | NP_001161072.1 |
| UniProt Secondary Accession: | Q8WWR8,Q96D64, A8K056, J3KNJ5, |
| UniProt Related Accession: | Q8WWR8 |
| Molecular Weight: | 53,066 Da |
| NCBI Full Name: | sialidase-4 isoform 3 |
| NCBI Synonym Full Names: | neuraminidase 4 |
| NCBI Official Symbol: | NEU4 |
| NCBI Protein Information: | sialidase-4 |
| UniProt Protein Name: | Sialidase-4 |
| UniProt Synonym Protein Names: | N-acetyl-alpha-neuraminidase 4 |
| Protein Family: | Sialidase |
| UniProt Gene Name: | NEU4 |
| UniProt Entry Name: | NEUR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NEU4 antibody (CAB5141) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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