Metabolism Antibodies 1

Anti-NEU3 Antibody (CAB13842)

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SKU:
CAB13842
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-NEU3 Antibody
Antibody SKU:CAB13842
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 222-461 of human NEU3 (NP_006647.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 222-461 of human NEU3 (NP_006647.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CFQL PCKT RPHS LMIY SDDL GVTW HHGR LIRP MVTV ECEV AEVT GRAG HPVL YCSA RTPN RCRA EALS TDHG EGFQ RLAL SRQL CEPP HGCQ GSVV SFRP LEIP HRCQ DSSS KDAP TIQQ SSPG SSLR LEEE AGTP SESW LLYS HPTS RKQR VDLG IYLN QTPL EAAC WSRP WILH CGPC GYSD LAAL EEEG LFGC LFEC GTKQ ECEQ IAFR LFTH REIL SHLQ GDCT SPGR NPSQ FKSN
Gene ID:10825
Uniprot:Q9UQ49
Cellular Location:Cell membrane, Peripheral membrane protein
Calculated MW:48kDa/51kDa
Observed MW:48kDa
Synonyms:NEU3, SIAL3
Background:This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.
UniProt Protein Function:NEU3: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family.
UniProt Protein Details:

Protein type:EC 3.2.1.18; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: cytoplasm; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function:alpha-sialidase activity; exo-alpha-sialidase activity

Biological Process: carbohydrate metabolic process; ganglioside catabolic process; glycosphingolipid metabolic process; oligosaccharide catabolic process

NCBI Summary:This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UQ49
NCBI GenInfo Identifier:117190519
NCBI Gene ID:10825
NCBI Accession:NP_006647.3
UniProt Secondary Accession:Q9UQ49,Q9NQE1, A8K327,
UniProt Related Accession:Q9UQ49
Molecular Weight:
NCBI Full Name:sialidase-3
NCBI Synonym Full Names:neuraminidase 3
NCBI Official Symbol:NEU3  
NCBI Official Synonym Symbols:SIAL3  
NCBI Protein Information:sialidase-3
UniProt Protein Name:Sialidase-3
UniProt Synonym Protein Names:Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3
Protein Family:Sialidase
UniProt Gene Name:NEU3  
UniProt Entry Name:NEUR3_HUMAN
Anti-NEU3 Antibody (CAB13842)Western blot analysis of extracts of various cells, using NEU3 antibody (CAB13842) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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