Cell Death Antibodies 2

Anti-Netrin receptor DCC Antibody (CAB9372)

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SKU:
CAB9372
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-Netrin receptor DCC Antibody
Antibody SKU:CAB9372
Antibody Size:50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human DCC
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:A synthetic peptide of human DCC
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1630
Uniprot:P43146
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:158kDa
Observed MW:158KDa
Synonyms:DCC, CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
Background:This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
UniProt Protein Function:DCC: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Defects in DCC are the cause of mirror movements type 1 (MRMV1). A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Belongs to the immunoglobulin superfamily. DCC family.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Tumor suppressor; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: axon; integral to membrane; plasma membrane; cytosol; lipid raft

Molecular Function:identical protein binding; protein binding; netrin receptor activity; transmembrane receptor activity; transcription coactivator activity

Biological Process: axon guidance; axonogenesis; spinal cord ventral commissure morphogenesis; positive regulation of apoptosis; apoptosis; response to amphetamine; neuron migration; negative regulation of collateral sprouting; dorsal/ventral axon guidance; anterior/posterior axon guidance

Disease: Mirror Movements 1; Esophageal Cancer; Colorectal Cancer

NCBI Summary:This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
UniProt Code:P43146
NCBI GenInfo Identifier:296434474
NCBI Gene ID:1630
NCBI Accession:P43146.2
UniProt Related Accession:P43146
Molecular Weight:
NCBI Full Name:Netrin receptor DCC
NCBI Synonym Full Names:DCC netrin 1 receptor
NCBI Official Symbol:DCC  
NCBI Official Synonym Symbols:CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1  
NCBI Protein Information:netrin receptor DCC; colorectal tumor suppressor; colorectal cancer suppressor; tumor suppressor protein DCC; deleted in colorectal carcinoma; deleted in colorectal cancer protein; immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1
UniProt Protein Name:Netrin receptor DCC
UniProt Synonym Protein Names:Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
Protein Family:DCC family protein
UniProt Gene Name:DCC  
UniProt Entry Name:DCC_HUMAN
Anti-Netrin receptor DCC Polyclonal Antibody (CAB9372)Western blot analysis of extracts of Mouse brain, using DCC antibody (CAB9372) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 300s.
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