Cell Biology Antibodies 12

Anti-Neogenin Antibody (CAB9413)

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SKU:
CAB9413
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Neogenin Antibody
Antibody SKU:CAB9413
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human NEO1 (NP_002490.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human NEO1 (NP_002490.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSSV YAGN NAIL NCEV NADL VPFV RWEQ NRQP LLLD DRVI KLPS GMLV ISNA TEGD GGLY RCVV ESGG PPKY SDEV ELKV LPDP EVIS DLVF LKQP SPLV RVIG QDVV LPCV ASGL PTPT IKWM KNEE ALDT ESSE RLVL LAGG SLEI SDVT EDDA GTYF CIAD NGNE TIEA QAEL TVQA Q
Gene ID:4756
Uniprot:Q92859
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:154kDa/158kDa/160kDa
Observed MW:160kDa
Synonyms:NEO1, IGDCC2, NGN, NTN1R2, neogenin
Background:This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:NEO1: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. Belongs to the immunoglobulin superfamily. DCC family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q22.3-q23

Cellular Component: Golgi apparatus; nucleoplasm; plasma membrane

Biological Process: iron ion homeostasis

NCBI Summary:This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
UniProt Code:Q92859
NCBI GenInfo Identifier:116242676
NCBI Gene ID:4756
NCBI Accession:Q92859.2
UniProt Secondary Accession:Q92859,O00340, Q17RX1, B7ZKM9, B7ZKN0,
UniProt Related Accession:Q92859
Molecular Weight:158,827 Da
NCBI Full Name:Neogenin
NCBI Synonym Full Names:neogenin 1
NCBI Official Symbol:NEO1  
NCBI Official Synonym Symbols:NGN; IGDCC2; NTN1R2  
NCBI Protein Information:neogenin
UniProt Protein Name:Neogenin
UniProt Synonym Protein Names:Immunoglobulin superfamily DCC subclass member 2
Protein Family:Neogenin
UniProt Gene Name:NEO1  
UniProt Entry Name:NEO1_HUMAN
Anti-Neogenin Polyclonal Antibody (CAB9413)Western blot analysis of extracts of MCF-7 cells, using NEO1 antibody (CAB9413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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