Anti-NELFCD Antibody (CAB4741)

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SKU:
CAB4741
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NELFCD
Synonyms:
HSPC130
Synonyms:
NELF-C
Synonyms:
NELF-D
Synonyms:
TH1
Synonyms:
TH1L

Description

Product Name:NELFCD Rabbit pAb
Product Code:CAB4741
Size:20uL, 50uL, 100uL
Synonyms:NELFCD, HSPC130, NELF-C, NELF-D, TH1, TH1L
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 355-599 of human NELFCD (NP_945327.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HCT116, 293T, NCI-H460, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 355-599 of human NELFCD (NP_945327.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARIN QDHK HKYI HILA YAAS VVET WKKN KRVS INKD ELKS TSKA VETV HNLC CNEN KGAS ELVA ELST LYQC IRFP VVAM GVLK WVDW TVSE PRYF QLQT DHTP VHLA LLDE ISTC HQLL HPQV LQLL VKLF ETEH SQLD VMEQ LELK KTLL DRMV HLLS RGYV LPVV SYIR KCLE KLDT DISL IRYF VTEV LDVI APPY TSDF VQLF LPIL ENDS IAGT IKTE GEHD PVTE FIAH CKSN FIMV N
Gene ID:51497
Uniprot:Q8IXH7
Cellular Location:Nucleus
Calculated MW:22kDa/65kDa/66kDa
Observed MW:66KDa
UniProt Protein Function:NELFCD: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E. Interacts with ARAF1. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. Belongs to the NELF-D family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold Chromosomal Location of Human Ortholog: 20q13 Cellular Component: nucleoplasm; membrane Molecular Function: protein binding Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IXH7
NCBI GenInfo Identifier:38372376
NCBI Gene ID:51497
NCBI Accession:Q8IXH7.2
UniProt Secondary Accession:Q8IXH7
UniProt Related Accession:Q8IXH7
Molecular Weight:Observed: 66 kDaPredicted: 67 kDa
NCBI Full Name:Negative elongation factor C/D
NCBI Synonym Full Names:negative elongation factor complex member C/D
NCBI Official Symbol:NELFCD  
NCBI Official Synonym Symbols:TH1; TH1L; NELF-C; NELF-D; HSPC130  
NCBI Protein Information:negative elongation factor C/D
UniProt Protein Name:Negative elongation factor C/D
UniProt Synonym Protein Names:TH1-like protein
Protein Family:
UniProt Gene Name:NELFCD  
UniProt Entry Name:NELFD_HUMAN
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