| UniProt Protein Function: | NELFCD: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E. Interacts with ARAF1. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. Belongs to the NELF-D family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold Chromosomal Location of Human Ortholog: 20q13 Cellular Component: nucleoplasm; membrane Molecular Function: protein binding Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IXH7 |
| NCBI GenInfo Identifier: | 38372376 |
| NCBI Gene ID: | 51497 |
| NCBI Accession: | Q8IXH7.2 |
| UniProt Secondary Accession: | Q8IXH7 |
| UniProt Related Accession: | Q8IXH7 |
| Molecular Weight: | Observed: 66 kDaPredicted: 67 kDa |
| NCBI Full Name: | Negative elongation factor C/D |
| NCBI Synonym Full Names: | negative elongation factor complex member C/D |
| NCBI Official Symbol: | NELFCD |
| NCBI Official Synonym Symbols: | TH1; TH1L; NELF-C; NELF-D; HSPC130 |
| NCBI Protein Information: | negative elongation factor C/D |
| UniProt Protein Name: | Negative elongation factor C/D |
| UniProt Synonym Protein Names: | TH1-like protein |
| Protein Family: | |
| UniProt Gene Name: | NELFCD |
| UniProt Entry Name: | NELFD_HUMAN |
