Cell Cycle Antibodies 2
Anti-NEK2 Antibody (CAB6811)
- SKU:
- CAB6811
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-NEK2 Antibody |
| Antibody SKU: | CAB6811 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NEK2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, Mouse testis, Rat testis |
| Immunogen: | A synthesized peptide derived from human NEK2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4751 |
| Uniprot: | P51955 |
| Cellular Location: | |
| Calculated MW: | 48/44kDa |
| Observed MW: | 50KDa |
| Synonyms: | HsPK21, NEK2A, NLK1, PPP1R111, RP67 |
| Background: | This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Protein Function: | NEK2: a protein kinase of the NEK family. Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Phosphorylation of Hec1 by Nek2 is essential for faithful chromosome segregation |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Nucleolus; Protein kinase, Other; EC 2.7.11.1; Other group; NEK family Chromosomal Location of Human Ortholog: 1q32.3 Cellular Component: kinetochore; spindle pole; microtubule; centrosome; intercellular bridge; protein complex; condensed nuclear chromosome; cytoplasm; nucleolus; midbody; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; metal ion binding; protein phosphatase binding; ATP binding; protein kinase activity Biological Process: mitosis; blastocyst development; regulation of attachment of spindle microtubules to kinetochore; mitotic sister chromatid segregation; protein amino acid autophosphorylation; regulation of mitotic centrosome separation; organelle organization and biogenesis; centrosome separation; spindle assembly; protein amino acid phosphorylation; negative regulation of DNA binding; chromosome segregation; meiotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of mitosis; mitotic cell cycle; G2/M transition of mitotic cell cycle Disease: Retinitis Pigmentosa 67 |
| NCBI Summary: | This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | P51955 |
| NCBI GenInfo Identifier: | 1709252 |
| NCBI Gene ID: | 4751 |
| NCBI Accession: | P51955.1 |
| UniProt Secondary Accession: | P51955,Q53FD6, Q5I1Z9, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2 Q96QN9, |
| UniProt Related Accession: | P51955 |
| Molecular Weight: | 445 |
| NCBI Full Name: | Serine/threonine-protein kinase Nek2 |
| NCBI Synonym Full Names: | NIMA-related kinase 2 |
| NCBI Official Symbol: | NEK2 |
| NCBI Official Synonym Symbols: | NLK1; RP67; NEK2A; HsPK21; PPP1R111 |
| NCBI Protein Information: | serine/threonine-protein kinase Nek2; nimA-like protein kinase 1; nimA-related protein kinase 2; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis gene a)-related kinase 2 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek2 |
| UniProt Synonym Protein Names: | HSPK 21; Never in mitosis A-related kinase 2; NimA-related protein kinase 2; NimA-like protein kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | NEK2 |
| UniProt Entry Name: | NEK2_HUMAN |
 | Western blot - NEK2 Rabbit mAb (CAB6811) |
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