Cell Cycle Antibodies 1
Anti-NEK1 Antibody (CAB16059)
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- SKU:
- CAB16059
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-NEK1 Antibody |
| Antibody SKU: | CAB16059 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEKY VRLQ KIGE GSFG KAIL VKST EDGR QYVI KEIN ISRM SSKE REES RREV AVLA NMKH PNIV QYRE SFEE NGSL YIVM DYCE GGDL FKRI NAQK GVLF |
| Gene ID: | 4750 |
| Uniprot: | Q96PY6 |
| Cellular Location: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 60kDa/135kDa/138kDa/141kDa/142kDa/145kDa |
| Observed MW: | Refer to figures |
| Synonyms: | NEK1, NY-REN-55, SRPS2, SRPS2A, SRTD6 |
| Background: | The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Other group; NEK family Chromosomal Location of Human Ortholog: 4q33 Cellular Component: centrosome; cytoplasm; nucleus; pericentriolar material Molecular Function:kinase activity; protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: cilium biogenesis; protein amino acid phosphorylation Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly |
| NCBI Summary: | The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q96PY6 |
| NCBI GenInfo Identifier: | 22256934 |
| NCBI Gene ID: | 4750 |
| NCBI Accession: | Q96PY6.2 |
| UniProt Secondary Accession: | Q96PY6,Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7 Q9Y594, G5E9Z3, |
| UniProt Related Accession: | Q96PY6 |
| Molecular Weight: | 141,053 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Nek1 |
| NCBI Synonym Full Names: | NIMA related kinase 1 |
| NCBI Official Symbol: | NEK1 |
| NCBI Official Synonym Symbols: | SRPS2; SRTD6; SRPS2A; NY-REN-55 |
| NCBI Protein Information: | serine/threonine-protein kinase Nek1 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek1 |
| UniProt Synonym Protein Names: | Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | NEK1 |
| UniProt Entry Name: | NEK1_HUMAN |
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