Cell Cycle Antibodies 1

Anti-NEK1 Antibody (CAB16059)

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SKU:
CAB16059
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-NEK1 Antibody
Antibody SKU:CAB16059
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human NEK1 (NP_036356.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEKY VRLQ KIGE GSFG KAIL VKST EDGR QYVI KEIN ISRM SSKE REES RREV AVLA NMKH PNIV QYRE SFEE NGSL YIVM DYCE GGDL FKRI NAQK GVLF
Gene ID:4750
Uniprot:Q96PY6
Cellular Location:Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:60kDa/135kDa/138kDa/141kDa/142kDa/145kDa
Observed MW:Refer to figures
Synonyms:NEK1, NY-REN-55, SRPS2, SRPS2A, SRTD6
Background:The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Other group; NEK family

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: centrosome; cytoplasm; nucleus; pericentriolar material

Molecular Function:kinase activity; protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: cilium biogenesis; protein amino acid phosphorylation

Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly

NCBI Summary:The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96PY6
NCBI GenInfo Identifier:22256934
NCBI Gene ID:4750
NCBI Accession:Q96PY6.2
UniProt Secondary Accession:Q96PY6,Q05DG5, Q14CB7, Q5H9T1, Q6PIB8, Q96SS2, Q9H6P7 Q9Y594, G5E9Z3,
UniProt Related Accession:Q96PY6
Molecular Weight:141,053 Da
NCBI Full Name:Serine/threonine-protein kinase Nek1
NCBI Synonym Full Names:NIMA related kinase 1
NCBI Official Symbol:NEK1  
NCBI Official Synonym Symbols:SRPS2; SRTD6; SRPS2A; NY-REN-55  
NCBI Protein Information:serine/threonine-protein kinase Nek1
UniProt Protein Name:Serine/threonine-protein kinase Nek1
UniProt Synonym Protein Names:Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:NEK1  
UniProt Entry Name:NEK1_HUMAN
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