Cell Biology Antibodies 17
Anti-NEFM Antibody (CAB19085)
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- SKU:
- CAB19085
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NEFM Antibody |
| Antibody SKU: | CAB19085 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NEFM |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | 293T, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human NEFM |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4741 |
| Uniprot: | P07197 |
| Cellular Location: | |
| Calculated MW: | 160kDa |
| Observed MW: | 160kDa |
 | Western blot - NEFM Rabbit mAb (CAB19085) |
| Synonyms: | NEF3, NF-M, NFM, NEFM |
| Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
| UniProt Protein Function: | NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 8p21 Cellular Component: axon; neurofilament; neuromuscular junction Molecular Function:protein binding; structural constituent of cytoskeleton; microtubule binding Biological Process: neurofilament bundle assembly; axon cargo transport; regulation of axon diameter; microtubule cytoskeleton organization and biogenesis |
| NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P07197 |
| NCBI GenInfo Identifier: | 281185500 |
| NCBI Gene ID: | 4741 |
| NCBI Accession: | P07197.3 |
| UniProt Secondary Accession: | P07197,Q4QRK6, B4DGN2, E9PBF7, |
| UniProt Related Accession: | P07197 |
| Molecular Weight: | 59,599 Da |
| NCBI Full Name: | Neurofilament medium polypeptide |
| NCBI Synonym Full Names: | neurofilament, medium polypeptide |
| NCBI Official Symbol: | NEFM |
| NCBI Official Synonym Symbols: | NFM; NEF3; NF-M |
| NCBI Protein Information: | neurofilament medium polypeptide; neurofilament 3; 160 kDa neurofilament protein; neurofilament triplet M protein; neurofilament-3 (150 kD medium); neurofilament, medium polypeptide 150kDa |
| UniProt Protein Name: | Neurofilament medium polypeptide |
| UniProt Synonym Protein Names: | 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein |
| Protein Family: | Neurofilament medium polypeptide |
| UniProt Gene Name: | NEFM |
| UniProt Entry Name: | NFM_HUMAN |
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