Cell Biology Antibodies 17

Anti-Nectin 2/CD112 Antibody (CAB9622)

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SKU:
CAB9622
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Nectin 2/CD112 Antibody
Antibody SKU:CAB9622
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Nectin 2/CD112
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, SH-SY5Y
Immunogen:A synthesized peptide derived from human Nectin 2/CD112
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5819
Uniprot:Q92692
Cellular Location:
Calculated MW:62-75kDa
Observed MW:72KDa
Synonyms:CD112, HVEB, PRR2, PVRL2, PVRR2
Background:This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Function:Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
NCBI Summary:This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q92692
NCBI GenInfo Identifier:12643789
NCBI Gene ID:5819
NCBI Accession:Q92692.1
UniProt Secondary Accession:Q92692,O75455, Q6IBI6, Q96J29, A8K5L5,
UniProt Related Accession:Q92692
Molecular Weight:
NCBI Full Name:Nectin-2
NCBI Synonym Full Names:nectin cell adhesion molecule 2
NCBI Official Symbol:NECTIN2  
NCBI Official Synonym Symbols:HVEB; PRR2; CD112; PVRL2; PVRR2  
NCBI Protein Information:nectin-2
UniProt Protein Name:Nectin-2
UniProt Synonym Protein Names:Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Poliovirus receptor-related protein 2; CD_antigen: CD112
UniProt Gene Name:PVRL2  
UniProt Entry Name:PVRL2_HUMAN
Anti-Nectin 2/CD112 Antibody (CAB9622)Western blot - Nectin 2/CD112 Rabbit mAb (CAB9622)
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system_update_altDatasheetHuman CD112/Nectin-2 Recombinant Protein CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain