Cell Biology Antibodies 11
Anti-NDUFS7 Antibody (CAB7862)
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- SKU:
- CAB7862
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NDUFS7 Antibody |
| Antibody SKU: | CAB7862 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-213 of human NDUFS7 (NP_077718.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-213 of human NDUFS7 (NP_077718.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSST QPAL PKAR AVAP KPSS RGEY VVAK LDDL VNWA RRSS LWPM TFGL ACCA VEMM HMAA PRYD MDRF GVVF RASP RQSD VMIV AGTL TNKM APAL RKVY DQMP EPRY VVSM GSCA NGGG YYHY SYSV VRGC DRIV PVDI YIPG CPPT AEAL LYGI LQLQ RKIK RERR LQIW YRR |
| Gene ID: | 374291 |
| Uniprot: | O75251 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 22kDa/23kDa |
| Observed MW: | 24kDa |
| Synonyms: | NDUFS7, CI-20, CI-20KD, MY017, PSST |
| Background: | This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. |
| UniProt Protein Function: | NDUFS7: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in NDUFS7 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in NDUFS7 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I 20 kDa subunit family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Energy Metabolism - oxidative phosphorylation; EC 1.6.5.3; Oxidoreductase; EC 1.6.99.3 Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: mitochondrial matrix; mitochondrial respiratory chain complex I Molecular Function:NADH dehydrogenase activity; protein binding Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly Disease: Leigh Syndrome |
| NCBI Summary: | This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75251 |
| NCBI GenInfo Identifier: | 90110040 |
| NCBI Gene ID: | 374291 |
| NCBI Accession: | O75251.3 |
| UniProt Secondary Accession: | O75251,Q2T9H7, Q9BV17, B3KRI2, |
| UniProt Related Accession: | O75251 |
| Molecular Weight: | 22,203 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase core subunit S7 |
| NCBI Official Symbol: | NDUFS7 |
| NCBI Official Synonym Symbols: | PSST; CI-20; MY017; CI-20KD |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial |
| UniProt Synonym Protein Names: | Complex I-20kD; CI-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit |
| Protein Family: | NADH dehydrogenase [ubiquinone] iron-sulfur protein |
| UniProt Gene Name: | NDUFS7 |
| UniProt Entry Name: | NDUS7_HUMAN |
 | Western blot analysis of extracts of mouse skeletal muscle, using NDUFS7 antibody (CAB7862) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using NDUFS7 antibody (CAB7862) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using NDUFS7 antibody (CAB7862) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using NDUFS7 antibody (CAB7862) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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