Cell Biology Antibodies 13

Anti-NDST1 Antibody (CAB17498)

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SKU:
CAB17498
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NDST1 Antibody
Antibody SKU:CAB17498
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-170 of human NDST1 (NP_001534.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-170 of human NDST1 (NP_001534.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GWKR GLEP SADA PEPD CGDP PPVA PSRL LPLK PVQA ATPS RTDP LVLV FVES LYSQ LGQE VVAI LESS RFKY RTEI APGK GDMP TLTD KGRG RFAL IIYE NILK YVNL DAWN RELL DKYC VAYG VGII GFF
Gene ID:3340
Uniprot:P52848
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:HSST, MRT46, NST1, NDST1
Background:This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Protein Function:Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
NCBI Summary:This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:P52848
NCBI GenInfo Identifier:4505351
NCBI Gene ID:3340
NCBI Accession:NP_001534.1
UniProt Secondary Accession:P52848,Q96E57,
UniProt Related Accession:P52848
Molecular Weight:62,065 Da
NCBI Full Name:bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NCBI Synonym Full Names:N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NCBI Official Symbol:NDST1  
NCBI Official Synonym Symbols:HSST; NST1  
NCBI Protein Information:bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosam
UniProt Protein Name:Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
UniProt Synonym Protein Names:Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1
UniProt Gene Name:NDST1  
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