Anti-NCR3 Antibody (CAB7153)

Antibody Name:	Anti-NCR3 Antibody
Antibody SKU:	CAB7153
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human NCR3 (NP_667341.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Rat
Positive Samples:	Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human NCR3 (NP_667341.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	WVSQ PPEI RTLE GSSA FLPC SFNA SQGR LAIG SVTW FRDE VVPG KEVR NGTP EFRG RLAP LASS RFLH DHQA ELHI RDVR GHDA SIYV CRVE VLGL GVGT GNGT RLVV EKEH PQLG AGTV L
Gene ID:	259197
Uniprot:	O14931
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	16kDa/17kDa/18kDa/19kDa/20kDa/21kDa
Observed MW:	30kDa

Synonyms:

NCR3, 1C7, CD337, LY117, MALS, NKp30

Background:

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	NCR3: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Receptor, misc.; Apoptosis; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: integral to plasma membrane Biological Process: cell recognition; immune response; inflammatory response; positive regulation of natural killer cell mediated cytotoxicity Disease: Malaria, Mild, Susceptibility To
NCBI Summary:	The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
UniProt Code:	O14931
NCBI GenInfo Identifier:	47605770
NCBI Gene ID:	259197
NCBI Accession:	O14931.1
UniProt Secondary Accession:	O14931,O14930, O14932, O95667, O95668, O95669, Q5ST89 Q5ST90, Q5ST91, B0S8F2, B0S8F4, B0S8F5,
UniProt Related Accession:	O14931
Molecular Weight:	201
NCBI Full Name:	Natural cytotoxicity triggering receptor 3
NCBI Synonym Full Names:	natural cytotoxicity triggering receptor 3
NCBI Official Symbol:	NCR3
NCBI Official Synonym Symbols:	1C7; MALS; CD337; LY117; NKp30
NCBI Protein Information:	natural cytotoxicity triggering receptor 3; NK-p30; lymphocyte antigen 117; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein
UniProt Protein Name:	Natural cytotoxicity triggering receptor 3
UniProt Synonym Protein Names:	Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD_antigen: CD337
Protein Family:	Natural cytotoxicity triggering receptor
UniProt Gene Name:	NCR3
UniProt Entry Name:	NCTR3_HUMAN

Western blot analysis of extracts of rat liver, using NCR3 antibody (CAB7153) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

Antibodies	ELISA Kits
Anti-NCR3 Antibody (CAB12616)	Human NKp30/NCR3(Natural cytotoxicity triggering receptor 3) ELISA Kit
Anti-NCR3 Antibody (CAB14522)
NCR3 Antibody (PACO03797)
NCR3 Antibody (PACO06914)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)