Immunology Antibodies 1
Anti-NCR3 Antibody (CAB12616)
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- SKU:
- CAB12616
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-NCR3 Antibody |
| Antibody SKU: | CAB12616 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human NCR3 (NP_667341.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human NCR3 (NP_667341.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WVSQ PPEI RTLE GSSA FLPC SFNA SQGR LAIG SVTW FRDE VVPG KEVR NGTP EFRG RLAP LASS RFLH DHQA ELHI RDVR GHDA SIYV CRVE VLGL GVGT GNGT RLVV EKEH PQLG AGTV L |
| Gene ID: | 259197 |
| Uniprot: | O14931 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 16kDa/17kDa/18kDa/19kDa/20kDa/21kDa |
| Observed MW: | 30kDa |
| Synonyms: | NCR3, 1C7, CD337, LY117, MALS, NKp30 |
| Background: | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NCR3: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Apoptosis; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: integral to plasma membrane Biological Process: cell recognition; immune response; inflammatory response; positive regulation of natural killer cell mediated cytotoxicity Disease: Malaria, Mild, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] |
| UniProt Code: | O14931 |
| NCBI GenInfo Identifier: | 47605770 |
| NCBI Gene ID: | 259197 |
| NCBI Accession: | O14931.1 |
| UniProt Secondary Accession: | O14931,O14930, O14932, O95667, O95668, O95669, Q5ST89 Q5ST90, Q5ST91, B0S8F2, B0S8F4, B0S8F5, |
| UniProt Related Accession: | O14931 |
| Molecular Weight: | 201 |
| NCBI Full Name: | Natural cytotoxicity triggering receptor 3 |
| NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 3 |
| NCBI Official Symbol: | NCR3 |
| NCBI Official Synonym Symbols: | 1C7; MALS; CD337; LY117; NKp30 |
| NCBI Protein Information: | natural cytotoxicity triggering receptor 3; NK-p30; lymphocyte antigen 117; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein |
| UniProt Protein Name: | Natural cytotoxicity triggering receptor 3 |
| UniProt Synonym Protein Names: | Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD_antigen: CD337 |
| Protein Family: | Natural cytotoxicity triggering receptor |
| UniProt Gene Name: | NCR3 |
| UniProt Entry Name: | NCTR3_HUMAN |
 | Western blot analysis of extracts of Rat liver, using NCR3 antibody (CAB12616) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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