Cell Biology Antibodies 5

Anti-NCR1 Antibody (CAB14499)

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SKU:
CAB14499
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-NCR1 Antibody
Antibody SKU:CAB14499
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_001138929.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse spleen, Rat spleen, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_001138929.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SMFL LLKE GRSS HVQR GYGK VQAE FPLG PVTT AHRG TYRC FGSY NNHA WSFP SEPV KLLV TGDI ENTS LAPE DPTF PDTW GTYL LTTE TGLQ KDHA LWDH TAQN LLRM GLAF LVLV ALVW FLVE DWLS RKRT RERA SRAS TWEG RRRL NTQT L
Gene ID:9437
Uniprot:O76036
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:21kDa/22kDa/23kDa/32kDa/34kDa
Observed MW:46kDa
Synonyms:CD335, LY94, NK-p46, NKP46, NCR1
Background:
UniProt Protein Function:NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Apoptosis

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: SWI/SNF complex; integral to plasma membrane

Molecular Function:receptor signaling protein activity

Biological Process: regulation of natural killer cell mediated cytotoxicity; natural killer cell activation; cellular defense response; signal transduction

UniProt Code:O76036
NCBI GenInfo Identifier:47605775
NCBI Gene ID:9437
NCBI Accession:O76036.1
UniProt Secondary Accession:O76036,O76016, O76017, O76018, B0V3L2, B0V3L3, B0V3L4 B0V3L5, B8JL03,
UniProt Related Accession:O76036
Molecular Weight:34,409 Da
NCBI Full Name:Natural cytotoxicity triggering receptor 1
NCBI Synonym Full Names:natural cytotoxicity triggering receptor 1
NCBI Official Symbol:NCR1  
NCBI Official Synonym Symbols:LY94; CD335; NKP46; NK-p46  
NCBI Protein Information:natural cytotoxicity triggering receptor 1; NK cell-activating receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); natural killer cell p46-related protein
UniProt Protein Name:Natural cytotoxicity triggering receptor 1
UniProt Synonym Protein Names:Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD_antigen: CD335
Protein Family:Niemann-Pick type C-related protein
UniProt Gene Name:NCR1  
UniProt Entry Name:NCTR1_HUMAN
Anti-NCR1 Antibody (CAB14499)Western blot analysis of extracts of various cell lines, using NCR1 antibody (CAB14499) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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