Signal Transduction Antibodies 3
Anti-Nck Antibody (CAB9129)
- SKU:
- CAB9129
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Nck Antibody |
| Antibody SKU: | CAB9129 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Nck |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse lung, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human Nck |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4690 |
| Uniprot: | P16333 |
| Cellular Location: | |
| Calculated MW: | 47kDa |
| Observed MW: | 47KDa |
| Synonyms: | NCK, NCKalpha, nck-1 |
| Background: | The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010] |
| UniProt Protein Function: | NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3q21 Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; ribosome; protein phosphatase type 1 complex; intercellular junction; vesicle membrane; cytosol; nucleus Molecular Function:protein binding, bridging; protein domain specific binding; protein binding; receptor signaling complex scaffold activity; protein kinase inhibitor activity; SH3/SH2 adaptor activity; cytoskeletal adaptor activity; receptor tyrosine kinase binding; receptor binding Biological Process: lamellipodium biogenesis; axon guidance; positive regulation of translation in response to stress; T cell activation; negative regulation of peptidyl-serine phosphorylation; signal complex assembly; actin filament organization; response to other organism; T cell receptor signaling pathway; substrate-bound cell migration, cell extension; positive regulation of actin filament polymerization; negative regulation of protein kinase activity; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P16333 |
| NCBI GenInfo Identifier: | 127962 |
| NCBI Gene ID: | 4690 |
| NCBI Accession: | P16333.1 |
| UniProt Secondary Accession: | P16333,B7Z751, D3DNE3, |
| UniProt Related Accession: | P16333 |
| Molecular Weight: | 377 |
| NCBI Full Name: | Cytoplasmic protein NCK1 |
| NCBI Synonym Full Names: | NCK adaptor protein 1 |
| NCBI Official Symbol: | NCK1 |
| NCBI Official Synonym Symbols: | NCK; nck-1; NCKalpha |
| NCBI Protein Information: | cytoplasmic protein NCK1; NCK tyrosine kinase; melanoma NCK protein; SH2/SH3 adaptor protein NCK-alpha; non-catalytic region of tyrosine kinase |
| UniProt Protein Name: | Cytoplasmic protein NCK1 |
| UniProt Synonym Protein Names: | NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha |
| Protein Family: | Nck-associated protein |
| UniProt Gene Name: | NCK1 |
| UniProt Entry Name: | NCK1_HUMAN |
 | Western blot - Nck Rabbit mAb (CAB9129) |
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