Cell Biology Antibodies 13

Anti-NCEH1 Antibody (CAB17741)

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SKU:
CAB17741
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NCEH1 Antibody
Antibody SKU:CAB17741
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-440 of human NCEH1 (NP_065843.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:PC-3, BxPC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-440 of human NCEH1 (NP_065843.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HLLA LNFI IVSF GKKS AWSS AQVK VTDT DFDG VEVR VFEG PPKP EEPL KRSV VYIH GGGW ALAS AKIR YYDE LCTA MAEE LNAV IVSI EYRL VPKV YFPE QIHD VVRA TKYF LKPE VLQK YMVD PGRI CISG DSAG GNLA AALG QQFT QDAS LKNK LKLQ ALIY PVLQ ALDF NTPS YQQN VNTP ILPR YVMV KYWV DYFK GNYD FVQA MIVN NHTS LDVE EAAA VRAR LNWT SLLP ASFT KNYK PVVQ TTGN ARIV QELP QLLD ARSA PLIA DQAV LQLL PKTY ILTC EHDV LRDD GIMY AKRL ESAG VEVT LDHF EDGF HGCM IFTS WPTN FSVG IRTR NSYI KWLD QNL
Gene ID:57552
Uniprot:Q6PIU2
Cellular Location:
Calculated MW:
Observed MW:46kDa
Anti-NCEH1 Antibody (CAB17741)Western blot - NCEH1 Polyclonal Antibody (CAB17741)
Synonyms:AADACL1, NCEH, NCEH1
Background:
UniProt Protein Function:AADACL1: a single-pass type II membrane microsomal protein. Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine). Elevated in invasive cancer cells from several different tumor types. May be involved in the elevated neutral ether lipid content and elevated LPA signaling in cancer cells. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. A key enzymatic node regulating an ether lipid signaling network in cancer; regulates MAGE and lysophospholipid levels in invasive cancer cells. Three alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:Hydrolase; Membrane protein, integral; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Biological Process: lipid catabolic process

UniProt Code:Q6PIU2
NCBI GenInfo Identifier:226423952
NCBI Gene ID:57552
NCBI Accession:NP_001139750.1
UniProt Secondary Accession:Q6PIU2,Q86WZ1, Q9P2I4, B7Z2K4, B7Z3A1, B7Z5U2, B7Z906 B7ZAW6, F5H7K4,
UniProt Related Accession:Q6PIU2
Molecular Weight:
NCBI Full Name:neutral cholesterol ester hydrolase 1 isoform c
NCBI Synonym Full Names:neutral cholesterol ester hydrolase 1
NCBI Official Symbol:NCEH1  
NCBI Official Synonym Symbols:NCEH; AADACL1  
NCBI Protein Information:neutral cholesterol ester hydrolase 1; arylacetamide deacetylase-like 1
UniProt Protein Name:Neutral cholesterol ester hydrolase 1
UniProt Synonym Protein Names:Arylacetamide deacetylase-like 1
Protein Family:Neutral cholesterol ester hydrolase
UniProt Gene Name:NCEH1  
UniProt Entry Name:NCEH1_HUMAN
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