Cell Biology Antibodies 11
Anti-NCAM1 / CD56 Antibody (CAB7913)
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- SKU:
- CAB7913
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NCAM1 / CD56 Antibody |
| Antibody SKU: | CAB7913 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 759-858 of human NCAM1 / CD56 (NP_851996.2). |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 759-858 of human NCAM1 / CD56 (NP_851996.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LCGK AGPG AKGK DMEE GKAA FSKD ESKE PIVE VRTE EERT PNHD GGKH TEPN ETTP LTEP EKGP VEAK PECQ ETET KPAP AEVK TVPN DATQ TKEN ESKA |
| Gene ID: | 4684 |
| Uniprot: | P13591 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 40kDa/73kDa/80kDa/83kDa/93kDa/94kDa |
| Observed MW: | 160kDa |
| Synonyms: | CD56, MSK39, NCAM, NCAM1, NCAM1 /CD56 |
| Background: | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:identical protein binding Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion |
| NCBI Summary: | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P13591 |
| NCBI GenInfo Identifier: | 205830665 |
| NCBI Gene ID: | 4684 |
| NCBI Accession: | P13591.3 |
| UniProt Related Accession: | P13591 |
| Molecular Weight: | |
| NCBI Full Name: | Neural cell adhesion molecule 1 |
| NCBI Synonym Full Names: | neural cell adhesion molecule 1 |
| NCBI Official Symbol: | NCAM1 |
| NCBI Official Synonym Symbols: | CD56; NCAM; MSK39 |
| NCBI Protein Information: | neural cell adhesion molecule 1 |
| UniProt Protein Name: | Neural cell adhesion molecule 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD56 |
| UniProt Gene Name: | NCAM1 |
| UniProt Entry Name: | NCAM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NCAM1 / CD56 antibody (CAB7913) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using NCAM1 / CD56 Rabbit pAb (CAB7913) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using NCAM1 / CD56 Rabbit pAb (CAB7913) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using NCAM1 / CD56 antibody (CAB7913) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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