Cell Biology Antibodies 2
Anti-NCAM1 Antibody (CAB12112)
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- SKU:
- CAB12112
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NCAM1 Antibody |
| Antibody SKU: | CAB12112 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-720 of human NCAM1 (NP_851996.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-1080, SW480, 293T, LO2, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-720 of human NCAM1 (NP_851996.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LEFI LVQA DTPS SPSI DQVE PYSS TAQV QFDE PEAT GGVP ILKY KAEW RAVG EEVW HSKW YDAK EASM EGIV TIVG LKPE TTYA VRLA ALNG KGLG EISA ASEF KTQP VQGE PSAP KLEG QMGE DGNS IKVN LIKQ DDGG SPIR HYLV RYRA LSSE WKPE IRLP SGSD HVML KSLD WNAE YEVY VVAE NQQG KSKA AHFV FRTS AQPT AIPA NGSP TSGL S |
| Gene ID: | 4684 |
| Uniprot: | P13591 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 40kDa/73kDa/80kDa/83kDa/93kDa/94kDa |
| Observed MW: | 175kDa |
| Synonyms: | CD56, MSK39, NCAM, NCAM1, NCAM1 /CD56 |
| Background: | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:identical protein binding Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion |
| NCBI Summary: | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P13591 |
| NCBI GenInfo Identifier: | 205830665 |
| NCBI Gene ID: | 4684 |
| NCBI Accession: | P13591.3 |
| UniProt Related Accession: | P13591 |
| Molecular Weight: | |
| NCBI Full Name: | Neural cell adhesion molecule 1 |
| NCBI Synonym Full Names: | neural cell adhesion molecule 1 |
| NCBI Official Symbol: | NCAM1 |
| NCBI Official Synonym Symbols: | CD56; NCAM; MSK39 |
| NCBI Protein Information: | neural cell adhesion molecule 1 |
| UniProt Protein Name: | Neural cell adhesion molecule 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD56 |
| UniProt Gene Name: | NCAM1 |
| UniProt Entry Name: | NCAM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NCAM1 antibody (CAB12112) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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