Cell Biology Antibodies 11
Anti-NBR1 Antibody (CAB7562)
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- SKU:
- CAB7562
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NBR1 Antibody |
| Antibody SKU: | CAB7562 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NBR1 (NP_005890.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NBR1 (NP_005890.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEPQ VTLN VTFK NEIQ SFLV SDPE NTTW ADIE AMVK VSFD LNTI QIKY LDEE NEEV SINS QGEY EEAL KMAV KQGN QLQM QVHE GHHV VDEA PPPV VGAK RLAA RAGK KPLA HYSS LVRV LGSD MKTP EDPA VQSF PLVP CDTD QPQD KPPD WFTS YLET FREQ VVNE TVEK LEQK LHEK LVLQ NPSL GSCP SEVS MPTS EETL FLPE NQFS WHIA CNNC QRRI VGVR YQCS LCPS YNIC EDCE AGPY GHDT NHVL LKLR RPVV GSSE PFCH SKYS TPRL |
| Gene ID: | 4077 |
| Uniprot: | Q14596 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Lysosome, M line, autophagosome, myofibril, sarcomere |
| Calculated MW: | 103kDa/107kDa |
| Observed MW: | 110kDa |
| Synonyms: | NBR1, 1A1-3B, IAI3B, M17S2, MIG19 |
| Background: | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: membrane; lysosome; late endosome; M band; autophagic vacuole; cytoplasmic vesicle; cytosol Molecular Function:ubiquitin binding; protein binding; zinc ion binding; mitogen-activated protein kinase binding Biological Process: regulation of stress-activated MAPK cascade; macroautophagy; negative regulation of osteoblast differentiation; regulation of bone mineralization; protein oligomerization |
| NCBI Summary: | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q14596 |
| NCBI GenInfo Identifier: | 296439290 |
| NCBI Gene ID: | 4077 |
| NCBI Accession: | Q14596.3 |
| UniProt Related Accession: | Q14596 |
| Molecular Weight: | 103kDa; 107kDa |
| NCBI Full Name: | Next to BRCA1 gene 1 protein |
| NCBI Synonym Full Names: | NBR1 autophagy cargo receptor |
| NCBI Official Symbol: | NBR1 |
| NCBI Official Synonym Symbols: | IAI3B; M17S2; MIG19; 1A1-3B |
| NCBI Protein Information: | next to BRCA1 gene 1 protein |
| UniProt Protein Name: | Next to BRCA1 gene 1 protein |
| UniProt Synonym Protein Names: | Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B |
| Protein Family: | Next to BRCA1 gene 1 protein |
| UniProt Gene Name: | NBR1 |
| UniProt Entry Name: | NBR1_HUMAN |
 | Western blot analysis of extracts of SKOV3 cells, using NBR1 antibody (CAB7562) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90. |
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