Cell Biology Antibodies 9
Anti-NBR1 Antibody (CAB3949)
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- SKU:
- CAB3949
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NBR1 Antibody |
| Antibody SKU: | CAB3949 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human NBR1 |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Positive Samples: | Mouse testis |
| Immunogen: | Recombinant protein of human NBR1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4077 |
| Uniprot: | Q14596 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Lysosome, M line, autophagosome, myofibril, sarcomere |
| Calculated MW: | 103kDa/107kDa |
| Observed MW: | 120KDa |
| Synonyms: | NBR1, 1A1-3B, IAI3B, M17S2, MIG19 |
| Background: | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: membrane; lysosome; late endosome; M band; autophagic vacuole; cytoplasmic vesicle; cytosol Molecular Function:ubiquitin binding; protein binding; zinc ion binding; mitogen-activated protein kinase binding Biological Process: regulation of stress-activated MAPK cascade; macroautophagy; negative regulation of osteoblast differentiation; regulation of bone mineralization; protein oligomerization |
| NCBI Summary: | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q14596 |
| NCBI GenInfo Identifier: | 296439290 |
| NCBI Gene ID: | 4077 |
| NCBI Accession: | Q14596.3 |
| UniProt Related Accession: | Q14596 |
| Molecular Weight: | 103kDa; 107kDa |
| NCBI Full Name: | Next to BRCA1 gene 1 protein |
| NCBI Synonym Full Names: | NBR1 autophagy cargo receptor |
| NCBI Official Symbol: | NBR1 |
| NCBI Official Synonym Symbols: | IAI3B; M17S2; MIG19; 1A1-3B |
| NCBI Protein Information: | next to BRCA1 gene 1 protein |
| UniProt Protein Name: | Next to BRCA1 gene 1 protein |
| UniProt Synonym Protein Names: | Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B |
| Protein Family: | Next to BRCA1 gene 1 protein |
| UniProt Gene Name: | NBR1 |
| UniProt Entry Name: | NBR1_HUMAN |
 | Western blot analysis of extracts of Mouse testis, using NBR1 Rabbit pAb (CAB3949) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver, using NBR1 antibody (CAB3949). |
 | Immunoprecipitation analysis of extracts of K562 cells, using NBR1 antibody (CAB3949). |
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