Cell Biology Antibodies 6

Anti-NAXE Antibody (CAB15952)

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SKU:
CAB15952
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NAXE Antibody
Antibody SKU:CAB15952
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 48-170 of human NAXE (NP_658985.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, LO2, NIH/3T3, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 48-170 of human NAXE (NP_658985.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DSEV MAST VVKY LSQE EAQA VDQE LFNE YQFS VDQL MELA GLSC ATAI AKAY PPTS MSRS PPTV LVIC GPGN NGGD GLVC ARHL KLFG YEPT IYYP KRPN KPLF TALV TQCQ KMDI PFLG EMP
Gene ID:128240
Uniprot:Q8NCW5
Cellular Location:Mitochondrion, Secreted
Calculated MW:20kDa/31kDa
Observed MW:32kDa
Synonyms:NAXE, AIBP, APOA1BP, PEBEL, YJEFN1
Background:The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes.
UniProt Protein Function:APOA1BP: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Belongs to the nnrE/AIBP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 5.1.99.6; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; extracellular space; mitochondrion; intracellular membrane-bound organelle; cytoplasm; extracellular region; cilium

Molecular Function:protein binding; protein homodimerization activity; metal ion binding; nucleotide binding

Biological Process: NADH metabolic process; NADP metabolic process; protein homotetramerization

NCBI Summary:The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NCW5
NCBI GenInfo Identifier:91984773
NCBI Gene ID:128240
NCBI Accession:NP_658985.2
UniProt Secondary Accession:Q8NCW5,Q496C6, Q5T3I2, B4DGY3,
UniProt Related Accession:Q8NCW5
Molecular Weight:20,431 Da
NCBI Full Name:NAD(P)H-hydrate epimerase
NCBI Synonym Full Names:apolipoprotein A-I binding protein
NCBI Official Symbol:APOA1BP  
NCBI Official Synonym Symbols:AIBP; YJEFN1  
NCBI Protein Information:NAD(P)H-hydrate epimerase
UniProt Protein Name:NAD(P)H-hydrate epimerase
UniProt Synonym Protein Names:Apolipoprotein A-I-binding protein
UniProt Gene Name:APOA1BP  
UniProt Entry Name:NNRE_HUMAN
Anti-NAXE Antibody (CAB15952)Western blot analysis of extracts of various cell lines, using NAXE antibody (CAB15952) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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