Cell Biology Antibodies 11
Anti-NAT8B Antibody (CAB7203)
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- SKU:
- CAB7203
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NAT8B Antibody |
| Antibody SKU: | CAB7203 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-165 of human NAT8B (NP_057431.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-165 of human NAT8B (NP_057431.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WFLA KKPW TRYV DIAL RTDM SDIT KSYL SECG SCFW VGES EEKV VGTV GALP VDDP TLRE KRLQ LFHL SVDN EHRG QGIA KALV RTVL QFA |
| Gene ID: | 51471 |
| Uniprot: | Q9UHF3 |
| Cellular Location: | Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Single-pass type II membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 25kDa |
| Synonyms: | NAT8B, CML2, Hcml2, NAT8BP |
| Background: |
| UniProt Protein Function: | NAT8B: May play a role in regulation of gastrulation. Belongs to the camello family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.-; Acetyltransferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to membrane; ER-Golgi intermediate compartment Molecular Function:lysine N-acetyltransferase activity; N-acetyltransferase activity; protein binding Biological Process: beta-amyloid metabolic process; gastrulation with mouth forming second; peptidyl-lysine N6-acetylation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHF3 |
| NCBI GenInfo Identifier: | 74720822 |
| NCBI Gene ID: | 51471 |
| NCBI Accession: | Q9UHF3.1 |
| UniProt Secondary Accession: | Q9UHF3,Q0VAD9, Q6NT18, |
| UniProt Related Accession: | Q9UHF3 |
| Molecular Weight: | 227 |
| NCBI Full Name: | Putative N-acetyltransferase 8B |
| NCBI Synonym Full Names: | N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) |
| NCBI Official Symbol: | NAT8B |
| NCBI Official Synonym Symbols: | CML2; Hcml2; NAT8BP |
| NCBI Protein Information: | putative N-acetyltransferase 8B; NAT8B; ATase1; acetyltransferase 1; camello-like protein 2; N-acetyltransferase Camello 2; probable N-acetyltransferase 8B |
| UniProt Protein Name: | Putative N-acetyltransferase 8B |
| UniProt Synonym Protein Names: | Acetyltransferase 1; ATase1; Camello-like protein 2 |
| Protein Family: | Putative N-acetyltransferase |
| UniProt Gene Name: | NAT8B |
| UniProt Entry Name: | NAT8B_HUMAN |
 | Western blot analysis of extracts of rat brain, using NAT8B antibody (CAB7203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using NAT8B antibody (CAB7203) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using NAT8B antibody (CAB7203) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using NAT8B antibody (CAB7203) at dilution of 1:200 (40x lens). |
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