Signal Transduction Antibodies 1
Anti-NAT2 Antibody (CAB12766)
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- SKU:
- CAB12766
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-NAT2 Antibody |
| Antibody SKU: | CAB12766 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse heart, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TNKE FLNS HLLP KKKH QKIY LFTL EPRT IEDF ESMN TYLQ TSPT SSFI TTSF CSLQ TPEG VYCL VGFI LTYR KFNY KDNT DLVE FKTL TEEE VEEV LRNI FKIS LGRN LVPK PGDG SLTI |
| Gene ID: | 10 |
| Uniprot: | P11245 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 33kDa |
| Observed MW: | 36kDa |
| Synonyms: | NAT2, AAC2, NAT-2, PNAT |
| Background: | This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). |
| UniProt Protein Function: | NAT2: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Translation; Xenobiotic Metabolism - drug metabolism - other enzymes Chromosomal Location of Human Ortholog: 8p22 Cellular Component: cytosol Molecular Function:arylamine N-acetyltransferase activity; protein binding Biological Process: xenobiotic metabolic process Disease: Acetylation, Slow |
| NCBI Summary: | This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11245 |
| NCBI GenInfo Identifier: | 114238 |
| NCBI Gene ID: | 10 |
| NCBI Accession: | P11245.1 |
| UniProt Secondary Accession: | P11245,O43637, O60654, O60655, Q13146, Q16697, Q2MLE4 Q2MLF5, Q2MLG8, Q2MLJ6, Q2MLK4, Q2MLK6, |
| UniProt Related Accession: | P11245 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | Arylamine N-acetyltransferase 2 |
| NCBI Synonym Full Names: | N-acetyltransferase 2 |
| NCBI Official Symbol: | NAT2 |
| NCBI Official Synonym Symbols: | AAC2; PNAT; NAT-2 |
| NCBI Protein Information: | arylamine N-acetyltransferase 2 |
| UniProt Protein Name: | Arylamine N-acetyltransferase 2 |
| UniProt Synonym Protein Names: | Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2; Polymorphic arylamine N-acetyltransferase; PNAT |
| Protein Family: | N-terminal acetyltransferase |
| UniProt Gene Name: | NAT2 |
 | Western blot analysis of extracts of various cell lines, using NAT2 antibody (CAB12766) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat lung using NAT2 antibody (CAB12766) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using NAT2 antibody (CAB12766) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast using NAT2 antibody (CAB12766) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of 293T cells using NAT2 antibody (CAB12766) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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