Cell Biology Antibodies 12
Anti-Nardilysin Antibody (CAB9119)
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- SKU:
- CAB9119
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Nardilysin Antibody |
| Antibody SKU: | CAB9119 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, K-562, NIH/3T3, Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human NRD1 (NP_001095132.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGAE IEDD DEEG FDDE DEFD DEHD DDLD TEDN ELEE LEER AEAR KKTT EKQS AAAL CVGV GSFA DPDD LPGL AHFL EHMV FMGS LKYP DENG FDAF LKKH GGSD NAST DCER TVFQ FDVQ RKYF KEAL DRWA QFFI HPLM IRDA IDRE VEAV DSEY QLAR PSDA NRKE MLFG SLAR PGHP MGKF FWGN AETL KHEP RKNN IDTH ARLR EFWM RYYS SHYM TLVV QSKE TLDT LEKW VTEI F |
| Gene ID: | 4898 |
| Uniprot: | O43847 |
| Cellular Location: | |
| Calculated MW: | 131kDa/139kDa |
| Observed MW: | 131kDa |
| Synonyms: | NRDC, NRD1, hNRD1, hNRD2 |
| Background: | This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NRD1: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.24.61 Chromosomal Location of Human Ortholog: 1p32.2-p32.1 Cellular Component: cell surface; cytosol Molecular Function:epidermal growth factor binding; metalloendopeptidase activity; protein binding; zinc ion binding Biological Process: cell migration; cell proliferation; neuromuscular junction development; positive regulation of membrane protein ectodomain proteolysis; protein processing; regulation of endopeptidase activity |
| NCBI Summary: | This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | O43847 |
| NCBI GenInfo Identifier: | 29840826 |
| NCBI Gene ID: | 4898 |
| NCBI Accession: | O43847.2 |
| UniProt Secondary Accession: | O43847,O15241, O15242, Q5VUL0, Q96HB2, Q9NU57, A6NI41 |
| UniProt Related Accession: | O43847 |
| Molecular Weight: | 139,284 Da |
| NCBI Full Name: | Nardilysin |
| NCBI Synonym Full Names: | nardilysin convertase |
| NCBI Official Symbol: | NRDC |
| NCBI Official Synonym Symbols: | NRD1; hNRD1; hNRD2 |
| NCBI Protein Information: | nardilysin |
| UniProt Protein Name: | Nardilysin |
| UniProt Synonym Protein Names: | N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase |
| Protein Family: | Negative regulator of differentiation |
| UniProt Gene Name: | NRDC |
| UniProt Entry Name: | NRDC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NRD1 antibody (CAB9119) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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