Cell Biology Antibodies 9

Anti-NAPSA Antibody (CAB5594)

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SKU:
CAB5594
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NAPSA Antibody
Antibody SKU:CAB5594
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human NAPSA (NP_004842.1).
Application:WB IF
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human NAPSA (NP_004842.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TLIR IPLH RVQP GRRI LNLL RGWR EPAE LPKL GAPS PGDK PIFV PLSN YRDV QYFG EIGL GTPP QNFT VAFD TGSS NLWV PSRR CHFF SVPC WLHH RFDP KASS SFQA NGTK FAIQ YGTG RVDG ILSE DKLT IGGI KGAS VIFG EALW EPSL VFAF AHFD GILG LGFP ILSV EGVR PPMD VLVE QGLL DKPV FSFY LNRD PEEP DGGE LVLG GSDP AHYI PPLT FV
Gene ID:9476
Uniprot:O96009
Cellular Location:Secreted
Calculated MW:45kDa
Observed MW:45kDa
Synonyms:NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin-A, Napsin A
Background:This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma.
UniProt Protein Function:NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family.
UniProt Protein Details:

Protein type:EC 3.4.23.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; lysosome

Molecular Function:aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity

Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; surfactant homeostasis

NCBI Summary:This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]
UniProt Code:O96009
NCBI GenInfo Identifier:6225749
NCBI Gene ID:9476
NCBI Accession:O96009.1
UniProt Secondary Accession:O96009,Q8WWD9,
UniProt Related Accession:O96009
Molecular Weight:45,387 Da
NCBI Full Name:Napsin-A
NCBI Synonym Full Names:napsin A aspartic peptidase
NCBI Official Symbol:NAPSA  
NCBI Official Synonym Symbols:KAP; Kdap; NAP1; NAPA; SNAPA  
NCBI Protein Information:napsin-A
UniProt Protein Name:Napsin-A
UniProt Synonym Protein Names:Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02
Protein Family:Napsin
UniProt Gene Name:NAPSA  
Anti-NAPSA Antibody (CAB5594)Western blot analysis of extracts of 293T cells, using NAPSA antibody (CAB5594) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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