Cell Biology Antibodies 9

Anti-NANS Antibody (CAB4778)

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SKU:
CAB4778
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NANS
Synonyms:
HEL-S-100
Synonyms:
SAS
Synonyms:
SEMDCG
Synonyms:
SEMDG
Research Area:
Cell Biology

Description

Product Name:NANS Rabbit pAb
Product Code:CAB4778
Size:20uL, 50uL, 100uL
Synonyms:NANS, HEL-S-100, SAS, SEMDCG, SEMDG
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-359 of human NANS (NP_061819.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, OVCAR3, A-431
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-359 of human NANS (NP_061819.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AELV RSVR LVER ALGS PTKQ LLPC EMAC NEKL GKSV VAKV KIPE GTIL TMDM LTVK VGEP KGYP PEDI FNLV GKKV LVTV EEDD TIME ELVD NHGK KIKS
Gene ID:54187
Uniprot:Q9NR45
Calculated MW:40kDa
Observed MW:40kDa
UniProt Protein Function:NANS: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.5.1.57; Transferase; EC 2.5.1.56

Chromosomal Location of Human Ortholog: 9p24.1-p23

Cellular Component: cytoplasm; cytosol

Molecular Function:N-acylneuraminate-9-phosphate synthase activity; N-acetylneuraminate synthase activity; N-acylneuraminate cytidylyltransferase activity

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; lipopolysaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

NCBI Summary:This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NR45
NCBI GenInfo Identifier:20978759
NCBI Gene ID:54187
NCBI Accession:Q9NR45.2
UniProt Secondary Accession:Q9NR45,Q8WUV9, Q9BWS6, Q9NVD4, B2RE98,
UniProt Related Accession:Q9NR45
Molecular Weight:359
NCBI Full Name:Sialic acid synthase
NCBI Synonym Full Names:N-acetylneuraminic acid synthase
NCBI Official Symbol:NANS  
NCBI Official Synonym Symbols:SAS; HEL-S-100  
NCBI Protein Information:sialic acid synthase; N-acetylneuraminate synthase; sialic acid phosphate synthase; epididymis secretory protein Li 100; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphate synthase
UniProt Protein Name:Sialic acid synthase
UniProt Synonym Protein Names:N-acetylneuraminate synthase (EC:2.5.1.56); N-acetylneuraminate-9-phosphate synthase (EC:2.5.1.57); N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase
Protein Family:Sialic acid synthase
UniProt Gene Name:NANS  
UniProt Entry Name:SIAS_HUMAN
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