Cell Biology Antibodies 15
Anti-NANOS3 Antibody (CAB17925)
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- SKU:
- CAB17925
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NANOS3 Antibody |
| Antibody SKU: | CAB17925 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human NANOS3 (NP_001092092.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human NANOS3 (NP_001092092.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGTF DLWT DYLG LAHL VRAL SGKE GPET RLSP QPEP EPML EPVS ALEP MPAP ESVP VPGP KDQK RSLE SSPA PERL CSFC KHNG ESRA IYQS HVLK DEAG RVLC PILR DYVC PQCG ATRE RAHT RRFC PLTG QGYT SVYS HTTR NSAG KKLV RPDK AKTQ DTGH RRGG GGGA GFRG AGKS EPSP SCSP SMST |
| Gene ID: | 342977 |
| Uniprot: | P60323 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NANOS3, NANOS1L, NOS3, ZC2HC12C |
| Background: |
| UniProt Protein Function: | NANOS3: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. Belongs to the nanos family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 19p13.13 Cellular Component: perinuclear region of cytoplasm; stress granule; cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; RNA binding Biological Process: oogenesis; regulation of translation; regulation of cell cycle; multicellular organismal development; negative regulation of translation; spermatogenesis; germ cell development |
| UniProt Code: | P60323 |
| NCBI GenInfo Identifier: | 41688563 |
| NCBI Gene ID: | 342977 |
| NCBI Accession: | P60323.1 |
| UniProt Related Accession: | P60323 |
| Molecular Weight: | Observed Molecular Weight: (Observed)18kD.Predicted Molecular Weight: (Calculated)19kDa. |
| NCBI Full Name: | Nanos homolog 3 |
| NCBI Synonym Full Names: | nanos C2HC-type zinc finger 3 |
| NCBI Official Symbol: | NANOS3 |
| NCBI Official Synonym Symbols: | NOS3; NANOS1L; ZC2HC12C |
| NCBI Protein Information: | nanos homolog 3 |
| UniProt Protein Name: | Nanos homolog 3 |
| Protein Family: | Nanos |
| UniProt Gene Name: | NANOS3 |
| UniProt Entry Name: | NANO3_HUMAN |
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