Cell Death Antibodies 1

Anti-NAIP Antibody (CAB16924)

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SKU:
CAB16924
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-NAIP Antibody
Antibody SKU:CAB16924
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human NAIP (NP_075043.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human NAIP (NP_075043.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLRS IHFP IRGN KTSP RAHF SVLE TCFD KSQV PTID QDYA SAFE PMNE WERN LAEK EDNV KSYM DMQR RASP DLST GYWK LSPK QYKI PCLE VDVN DIDV V
Gene ID:4671
Uniprot:Q13075
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:NAIP, BIRC1, NLRB1, psiNAIP
Background:This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
UniProt Protein Function:BIRC1: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: basolateral plasma membrane; spindle microtubule; cytoplasm; nucleus

Molecular Function:protein binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ATP binding

Biological Process: nervous system development; regulation of signal transduction; innate immune response; protein ubiquitination; negative regulation of caspase activity; negative regulation of neuron apoptosis; inflammatory response; negative regulation of apoptosis

NCBI Summary:This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13075
NCBI GenInfo Identifier:219520065
NCBI Gene ID:4671
NCBI Accession:AAI43762.1
UniProt Secondary Accession:Q13075,O75857, Q13730, Q59GI6, Q8TDZ4, Q99796, B9EG72 E9PHD1,
UniProt Related Accession:Q13075
Molecular Weight:159,582 Da
NCBI Full Name:NAIP protein
NCBI Synonym Full Names:NLR family, apoptosis inhibitory protein
NCBI Official Symbol:NAIP  
NCBI Official Synonym Symbols:BIRC1; NLRB1; psiNAIP  
NCBI Protein Information:baculoviral IAP repeat-containing protein 1; neuronal apoptosis inhibitory protein; psi neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1
UniProt Protein Name:Baculoviral IAP repeat-containing protein 1
UniProt Synonym Protein Names:Neuronal apoptosis inhibitory protein
Protein Family:Putative niacin/nicotinamide transporter
UniProt Gene Name:NAIP  
UniProt Entry Name:BIRC1_HUMAN
Anti-NAIP Antibody (CAB16924)Western blot analysis of extracts of various cell lines, using NAIP antibody (CAB16924) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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