Cell Biology Antibodies 17
Anti-NABP2 Antibody (CAB18488)
- SKU:
- CAB18488
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-NABP2 Antibody |
Antibody SKU: | CAB18488 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human NABP2. |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Mouse |
Positive Samples: |
Immunogen: | Recombinant protein of human NABP2. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 79035 |
Uniprot: | Q9BQ15 |
Cellular Location: | |
Calculated MW: | |
Observed MW: | Refer to figures |
Synonyms: | OBFC2B, SOSS-B1, SSB1, hSSB1, NABP2 |
Background: |
UniProt Protein Function: | OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage; Cell cycle regulation Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:enzyme binding; protein binding; single-stranded DNA binding Biological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; regulation of telomerase activity; response to DNA damage stimulus; response to ionizing radiation; snRNA transcription from RNA polymerase II promoter |
NCBI Summary: | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] |
UniProt Code: | Q9BQ15 |
NCBI GenInfo Identifier: | 74761196 |
NCBI Gene ID: | 79035 |
NCBI Accession: | Q9BQ15.1 |
UniProt Secondary Accession: | Q9BQ15,Q6XYC8, A6NDF8, |
UniProt Related Accession: | Q9BQ15 |
Molecular Weight: | 11,493 Da |
NCBI Full Name: | SOSS complex subunit B1 |
NCBI Synonym Full Names: | nucleic acid binding protein 2 |
NCBI Official Symbol: | NABP2 |
NCBI Official Synonym Symbols: | SSB1; hSSB1; OBFC2B; SOSS-B1 |
NCBI Protein Information: | SOSS complex subunit B1 |
UniProt Protein Name: | SOSS complex subunit B1 |
UniProt Synonym Protein Names: | Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1 |
Protein Family: | SOSS complex |
UniProt Gene Name: | NABP2 |
UniProt Entry Name: | SOSB1_HUMAN |