Epigenetics & Nuclear Signaling Antibodies 2
Anti-NAB2 Antibody (CAB5827)
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- SKU:
- CAB5827
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NAB2 Antibody |
| Antibody SKU: | CAB5827 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NAB2 (NP_005958.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | M21, Mouse lung, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NAB2 (NP_005958.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHRA PSPT AEQP PGGG DSAR RTLQ PRLK PSAR AMAL PRTL GELQ LYRV LQRA NLLS YYET FIQQ GGDD VQQL CEAG EEEF LEIM ALVG MATK PLHV RRLQ KALR EWAT NPGL FSQP VPAV PVSS IPLF KISE TAGT RKGS MSNG HGSP GEKA GSAR SFSP KSPL ELGE KLSP LPGG PGAG DPRI WPGR STPE SDVG AGGE |
| Gene ID: | 4665 |
| Uniprot: | Q15742 |
| Cellular Location: | Nucleus |
| Calculated MW: | 34kDa/49kDa/56kDa |
| Observed MW: | 70kDa |
| Synonyms: | NAB2, MADER |
| Background: | This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. |
| UniProt Protein Function: | NAB2: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Belongs to the NAB family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: cell proliferation; negative regulation of transcription from RNA polymerase III promoter; nervous system development |
| NCBI Summary: | This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15742 |
| NCBI GenInfo Identifier: | 12643729 |
| NCBI Gene ID: | 4665 |
| NCBI Accession: | Q15742.1 |
| UniProt Secondary Accession: | Q15742,O76006, Q14797, B2RAK3, |
| UniProt Related Accession: | Q15742 |
| Molecular Weight: | 49,748 Da |
| NCBI Full Name: | NGFI-A-binding protein 2 |
| NCBI Synonym Full Names: | NGFI-A binding protein 2 |
| NCBI Official Symbol: | NAB2 |
| NCBI Official Synonym Symbols: | MADER |
| NCBI Protein Information: | NGFI-A-binding protein 2 |
| UniProt Protein Name: | NGFI-A-binding protein 2 |
| UniProt Synonym Protein Names: | EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER |
| Protein Family: | NGFI-A-binding protein |
| UniProt Gene Name: | NAB2 |
| UniProt Entry Name: | NAB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NAB2 antibody (CAB5827) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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