Epigenetics & Nuclear Signaling Antibodies 4
Anti-NAA60 Antibody (CAB7386)
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- SKU:
- CAB7386
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-NAA60 Antibody |
| Antibody SKU: | CAB7386 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human NAA60 (NP_079121.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human NAA60 (NP_079121.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEV VPSS ALSE VSLR LLCH DDID TVKH LCGD WFPI EYPD SWYR DITS NKKF FSLA ATYR GAIV GMIV AEIK NRTK IHKE DGDI LASN FSVD TQVA YILS LGVV KEFR KHGI GSLL LESL KDHI STTA QDHC KAIY LHVL TTNN TAIN FYEN RDFK QHHY LPYY YSIR GVLK DGFT YVLY INGG HPPW TILD YIQH LGSA LASL SPCS IPHR VYRQ AHSL LCSF LPWS GISS KSGI EYSR TM |
| Gene ID: | 79903 |
| Uniprot: | Q9H7X0 |
| Cellular Location: | Golgi apparatus membrane |
| Calculated MW: | 19kDa/20kDa/27kDa/28kDa |
| Observed MW: | 27kDa |
| Synonyms: | NAA60, HAT4, NAT15, NatF, hNaa60 |
| Background: | This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. |
| UniProt Protein Function: | NAT15: Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. Belongs to the acetyltransferase family. NAA60 subfamily. 5 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:EC 2.3.1.48; Acetyltransferase; EC 2.3.1.88 Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: Golgi membrane Molecular Function:peptide alpha-N-acetyltransferase activity; H4 histone acetyltransferase activity Biological Process: nucleosome assembly; cell proliferation; N-terminal peptidyl-methionine acetylation; chromosome segregation |
| UniProt Code: | Q9H7X0 |
| NCBI GenInfo Identifier: | 74733721 |
| NCBI Gene ID: | 79903 |
| NCBI Accession: | Q9H7X0.1 |
| UniProt Secondary Accession: | Q9H7X0,Q6IA31, Q6UX26, B3KRQ0, B4DLZ0, B4DPZ8, B4DYC4 D3DUC2, E7EQ65, |
| UniProt Related Accession: | Q9H7X0 |
| Molecular Weight: | 242 |
| NCBI Full Name: | N-alpha-acetyltransferase 60 |
| NCBI Synonym Full Names: | N(alpha)-acetyltransferase 60, NatF catalytic subunit |
| NCBI Official Symbol: | NAA60 |
| NCBI Official Synonym Symbols: | HAT4; NAT15 |
| NCBI Protein Information: | N-alpha-acetyltransferase 60; natF catalytic subunit; histone acetyltransferase type B protein 4; N-acetyltransferase 15 (GCN5-related, putative) |
| UniProt Protein Name: | N-alpha-acetyltransferase 60 |
| UniProt Synonym Protein Names: | Histone acetyltransferase type B protein 4; HAT4; N-acetyltransferase 15; NatF catalytic subunit |
| Protein Family: | N-alpha-acetyltransferase |
| UniProt Gene Name: | NAA60 |
| UniProt Entry Name: | NAA60_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NAA60 antibody (CAB7386) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using NAA60 antibody (CAB7386) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using NAA60 antibody (CAB7386) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric using NAA60 antibody (CAB7386) at dilution of 1:200 (40x lens). |
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