Cell Biology Antibodies 7

Anti-MYPN Antibody (CAB16584)

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SKU:
CAB16584
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MYPN Antibody
Antibody SKU:CAB16584
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MYPN (NP_115967.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MYPN (NP_115967.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQDD SIEA STSI SQLL RESY LAET RHRG NNER SRAE PSSN PCHF GSPS GAAE GGGG QDDL PDLS AFLS QEEL DESV NLAR LAIN YDPL EKAD ETQA RKRL SPDQ MKHS PNLS FEPN FCQD NPRS PTSS KESP QEAK RPQY CSET QSKK VFLN KAAD FIEE LSSL FKSH SSKR IRPR ACKN HKSK LESQ NKVM QENS SSFS DLSE RRER SSVP IPIP ADTR DNEV NHAL EQQE AKRR EAEQ AASE AAGG DT
Gene ID:84665
Uniprot:Q86TC9
Cellular Location:Cytoplasm, Nucleus, myofibril, sarcomere
Calculated MW:56kDa/114kDa/145kDa
Observed MW:145kDa
Synonyms:MYPN, CMD1DD, CMH22, MYOP, NEM11, RCM4
Background:Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:MYPN: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Belongs to the myotilin/palladin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Actin-binding

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: I band; nucleus; Z disc

Molecular Function:cytoskeletal protein binding; muscle alpha-actinin binding; protein binding; SH3 domain binding

Biological Process: sarcomere organization

Disease: Cardiomyopathy, Dilated, 1kk

NCBI Summary:Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Code:Q86TC9
NCBI GenInfo Identifier:13957727
NCBI Gene ID:84665
NCBI Accession:AAK50625.1
UniProt Secondary Accession:Q86TC9,Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5
UniProt Related Accession:Q86TC9
Molecular Weight:
NCBI Full Name:myopalladin
NCBI Synonym Full Names:myopalladin
NCBI Official Symbol:MYPN  
NCBI Official Synonym Symbols:MYOP; RCM4; CMH22; NEM11; CMD1DD  
NCBI Protein Information:myopalladin
UniProt Protein Name:Myopalladin
UniProt Synonym Protein Names:145 kDa sarcomeric protein
Protein Family:Myopalladin
UniProt Gene Name:MYPN  
Anti-MYPN Antibody (CAB16584)Western blot analysis of extracts of HepG2 cells, using MYPN antibody (CAB16584) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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