Epigenetics & Nuclear Signaling Antibodies 2

Anti-MYOCD Antibody (CAB16159)

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SKU:
CAB16159
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-MYOCD Antibody
Antibody SKU:CAB16159
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 650-750 of human MYOCD (NP_705832.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:Rat heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 650-750 of human MYOCD (NP_705832.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLPP SPNN PHFL PSSS GAQG EGHR VSSP ISSQ VCTA QMAG LHSS DKVG PKFS IPSP TFSK SSSA ISEV TQPP SYED AVKQ QMTR SQQM DELL DVLI ESGE M
Gene ID:93649
Uniprot:Q8IZQ8
Cellular Location:Nucleus
Calculated MW:73kDa/101kDa/106kDa
Observed MW:102kDa
Synonyms:MYOCD, MYCD, myocardin
Background:This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
NCBI Summary:This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:Q8IZQ8
NCBI GenInfo Identifier:54306542
NCBI Gene ID:93649
NCBI Accession:AAV33439.1
UniProt Secondary Accession:Q8IZQ8,Q5UBU5, Q8N7Q1,
UniProt Related Accession:Q8IZQ8
Molecular Weight:73,183 Da
NCBI Full Name:myocardin
NCBI Synonym Full Names:myocardin
NCBI Official Symbol:MYOCD  
NCBI Official Synonym Symbols:MYCD  
NCBI Protein Information:myocardin
UniProt Protein Name:Myocardin
Protein Family:Myocilin
UniProt Gene Name:MYOCD  
Anti-MYOCD Antibody (CAB16159)Western blot analysis of extracts of rat heart, using MYOCD antibody (CAB16159) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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