Cell Biology Antibodies 3
Anti-MYO6 Antibody (CAB13033)
- SKU:
- CAB13033
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-MYO6 Antibody |
Antibody SKU: | CAB13033 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1016-1285 of human MYO6 (NP_004990.3). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HT-29, Mouse brain, Mouse kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1016-1285 of human MYO6 (NP_004990.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | IAQS EAEL ISDE AQAD LALR RNDG TRPK MTPE QMAK EMSE FLSR GPAV LATK AAAG TKKY DLSK WKYA ELRD TINT SCDI ELLA ACRE EFHR RLKV YHAW KSKN KKRN TETE QRAP KSVT DYDF APFL NNSP QQNP AAQI PARQ REIE MNRQ QRFF RIPF IRPA DQYK DPQS KKKG WWYA HFDG PWIA RQME LHPD KPPI LLVA GKDD MEMC ELNL EETG LTRK RGAE ILPR QFEE IWER CGGI QYLQ NAIE SRQA RPTY ATAM LQSL LK |
Gene ID: | 4646 |
Uniprot: | Q9UM54 |
Cellular Location: | Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus, Peripheral membrane protein, Peripheral membrane protein, clathrin-coated pit, clathrin-coated vesicle membrane, perinuclear region, ruffle membrane, trans-Golgi network membrane |
Calculated MW: | 145kDa/146kDa/148kDa/149kDa |
Observed MW: | 150kDa |
Synonyms: | MYO6, DFNA22, DFNB37, Myo6-007, Myo6-008, myosin VI |
Background: | This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
UniProt Protein Function: | MYO6: a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins. |
UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 6q13 Cellular Component: cell cortex; clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; DNA-directed RNA polymerase II, holoenzyme; endocytic vesicle; filamentous actin; Golgi apparatus; lysosomal membrane; membrane; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle; unconventional myosin complex Molecular Function:actin binding; actin filament binding; ADP binding; calmodulin binding; motor activity; protein binding Biological Process: actin filament-based movement; DNA damage response, signal transduction by p53 class mediator; endocytosis; intracellular protein transport; positive regulation of transcription from RNA polymerase II promoter; regulation of secretion Disease: Deafness, Autosomal Dominant 22; Deafness, Autosomal Recessive 37 |
NCBI Summary: | This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q9UM54 |
NCBI GenInfo Identifier: | 122065628 |
NCBI Gene ID: | 4646 |
NCBI Accession: | Q9UM54.4 |
UniProt Secondary Accession: | Q9UM54,Q5TEM5, Q5TEM6, Q5TEM7, Q9BZZ7, Q9UEG2, A6H8V4 E1P540, |
UniProt Related Accession: | Q9UM54 |
Molecular Weight: | 148,659 Da |
NCBI Full Name: | Unconventional myosin-VI |
NCBI Synonym Full Names: | myosin VI |
NCBI Official Symbol: | MYO6 |
NCBI Official Synonym Symbols: | DFNA22; DFNB37 |
NCBI Protein Information: | unconventional myosin-VI |
UniProt Protein Name: | Unconventional myosin-VI |
UniProt Synonym Protein Names: | Unconventional myosin-6 |
Protein Family: | Unconventional myosin |
UniProt Gene Name: | MYO6 |
UniProt Entry Name: | MYO6_HUMAN |